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Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19.

二甲双胍和SARS-CoV-2: 空气污染应对新型冠状病毒肺炎细胞因子/血栓风暴的机制教训。

  • 影响因子:4.8310
  • DOI:10.18632/aging.103347
  • 作者列表:"Menendez JA
  • 发表时间:2020-05-27
Abstract

:Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease caused by infection with the novel coronavirus SARS-CoV-2. Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca2+ release-activated Ca2+ channels (CRAC)/IL-6 cascade. Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people. The incorporation of infection rates, severity and lethality of SARS-CoV-2 infections as new outcomes of metformin usage in elderly populations at risk of developing severe COVID-19, together with the assessment of bronchial/serological titers of inflammatory cytokines and D-dimers, could provide a novel mechanistic basis for the consideration of metformin as a therapeutic strategy against the inflammatory and thrombotic states underlying the gerolavic traits of SARS-CoV-2 infection.

摘要

颗粒物 (PM) 空气污染引起的肺部病理信号与新型冠状病毒肺炎引起的疾病部分重叠,新型冠状病毒是由SARS-CoV-2 感染引起的大流行性疾病。二甲双胍能够抑制城市PM空气污染的促炎症和促血栓形成过程的分子触发因素之一,即线粒体ROS/Ca2 + 释放激活的Ca2 + 通道 (CRAC)/IL-6 层叠。鉴于线粒体功能、离子通道和炎症老化之间的联系,二甲双胍靶向线粒体电子转运和阻止ROS/CRAC介导的IL-6 释放的能力可能会为平息主要原因的细胞因子和血栓样风暴提供新的治疗途径新型冠状病毒肺炎老年人的发病率和死亡率。将SARS-CoV-2 感染的感染率、严重程度和致死率纳入二甲双胍用于有发生严重新型冠状病毒肺炎风险的老年人群的新结局,与炎症细胞因子和D-二聚体的支气管/血清学滴度评估一起,为考虑二甲双胍作为治疗SARS-CoV-2 感染的炎症和血栓状态提供了新的机制基础。

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翻译标题与摘要 下载文献
影响因子:2.48
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DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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