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Merits and culprits of immunotherapies for neurological diseases in times of COVID-19.

新型冠状病毒肺炎时期神经系统疾病免疫治疗的优缺点。

  • 影响因子:6.68000
  • DOI:10.1016/j.ebiom.2020.102822
  • 作者列表:"Pawlitzki M","Zettl UK","Ruck T","Rolfes L","Hartung HP","Meuth SG
  • 发表时间:2020-06-01
Abstract

:Immunosuppression and immunomodulation are valuable therapeutic approaches for managing neuroimmunological diseases. In times of the Coronavirus disease 2019 (COVID-19) pandemic, clinicians must deal with the question of whether immunotherapy should currently be initiated or discontinued in neurological patients. Uncertainty exists especially because different national medical associations publish different recommendations on the extent to which immunotherapies must be continued, monitored, or possibly switched during the current pandemic. Based on the most recently available data both about the novel coronavirus and the approved immunotherapies for neurological diseases, we provide an updated overview that includes current treatment strategies and the associated COVID-19 risk, but also the potential of immunotherapies to treat COVID-19.

摘要

: 免疫抑制和免疫调节是管理神经免疫性疾病的有价值的治疗方法。在冠状病毒疾病 2019 (新型冠状病毒肺炎) 大流行时期,临床医生必须处理神经系统患者目前是否应该开始或停止免疫治疗的问题。存在不确定性,特别是因为不同的国家医学协会发布了不同的建议,在当前大流行期间,免疫疗法必须继续、监测或可能切换的程度。基于最新的数据,无论是关于神经系统疾病的新型冠状病毒和批准的免疫疗法,我们提供了一个更新的概述,包括当前的治疗策略和相关新型冠状病毒肺炎风险,还有免疫疗法治疗新型冠状病毒肺炎的潜力。

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影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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