The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019.
- 作者列表："Liu R","Ma Q","Han H","Su H","Liu F","Wu K","Wang W","Zhu C
:Background Among patients with coronavirus disease 2019 (COVID-19), the cases of a significant proportion of patients are severe. A viral nucleic acid test is used for the diagnosis of COVID-19, and some hematological indicators have been used in the auxiliary diagnosis and identification of the severity of COVID-19. Regarding body fluid samples, except for being used for nucleic acid testing, the relationship between COVID-19 and routine body fluid parameters is not known. Our aim was to investigate the value of urine biochemical parameters in the prediction of the severity of COVID-19. Methods A total of 119 patients with COVID-19 were enrolled at Renmin Hospital of Wuhan University. According to the severity of COVID-19, the patients were divided into three groups (moderate 67, severe 42 and critical 10), and 45 healthy persons were enrolled in the same period as healthy controls. The relationship between the results of urine biochemical parameters and the severity of COVID-19 was analyzed. Results The positive rates of urine occult blood (BLOOD) and proteinuria (PRO) were higher in COVID-19 patients than in healthy controls (p < 0.05); the urine specific gravity (SG) value was lower in patients than in healthy controls (p < 0.05), and the urine potential of hydrogen (pH) value was higher in patients than in healthy controls (p < 0.01). The positive rates of urine glucose (GLU-U) and PRO in the severe and critical groups were higher than those in the moderate group (p < 0.01 and p < 0.05, respectively); other biochemical parameters of urine were not associated with the severity of COVID-19. Conclusions Some urine biochemical parameters are different between patients with severe acute respiratory syndrome (SARS)-CoV-2 and healthy controls, and GLU-U and PRO may be helpful for the differentiation of COVID-19 severity.
背景: 在 2019 例冠状病毒疾病患者 (新型冠状病毒肺炎) 中，相当大比例的患者病情严重。病毒核酸test用于新型冠状病毒肺炎的诊断，一些血液学指标已用于新型冠状病毒肺炎的辅助诊断和严重程度的鉴定。关于体液样本，除用于核酸检测外，新型冠状病毒肺炎与常规体液参数的关系尚不清楚。我们的目的是探讨尿液生化指标在预测新型冠状病毒肺炎严重程度中的价值。方法入选武汉大学人民医院 119 例新型冠状病毒肺炎患者。根据新型冠状病毒肺炎的严重程度，将患者分为 3 组 (中度 67 例、重度 42 例、危重 10 例)，同时入选同期健康体检者 45 例作为健康对照。分析尿生化指标结果与新型冠状病毒肺炎严重程度的关系。结果新型冠状病毒肺炎患者尿潜血 (blood) 和蛋白尿 (PRO) 阳性率均高于健康对照组 (p <0.05); 尿比重 (SG) 患者的值低于健康对照组 (p <0.05)，尿氢电位 (pH)患者的值高于健康对照组 (p <0.01)。U rine gl u cose (GL U-U) 阳性率和PRO在重度和重症gro u ps高于中度gro u p (p <0.01 和p <0.05); 其他生化指标u海洋与ems的新型冠状病毒肺炎.Concl u sions一些u海洋生化参数差异重型交流u te呼吸道症候群 (传染性非典型肺炎)-CoV-2 及健康对照者，GL U-U和PRO可能是区分新型冠状病毒肺炎严重程度的helpf u l。
METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.