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Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients.

中国武汉冠状病毒病-19 感染的性别特异性临床特征和预后: 168 例重症患者的回顾性研究。

  • 影响因子:6.02
  • DOI:10.1371/journal.ppat.1008520
  • 作者列表:"Meng Y","Wu P","Lu W","Liu K","Ma K","Huang L","Cai J","Zhang H","Qin Y","Sun H","Ding W","Gui L","Wu P
  • 发表时间:2020-04-28
Abstract

:To confirm the relationship between sex and the progression of Coronavirus Disease-19 (COVID-19), and its potential mechanism, among severe patients. For this retrospective study, we included 168 consecutive severe patients with pathogen-confirmed COVID-19 who were hospitalized between January 16th and February 4th, 2020, at Tongji Hospital in Wuhan, China. Clinical characteristics, laboratory parameters, and outcomes were compared and analyzed between males and females. In the present study, we analyzed 168 severe patients with COVID-19, including 86 males and 82 females, and 48 patients (28.6%) were diagnosed as critically ill. Of 86 male patients, 12.8% (11/86) died and 75.6% (65/86) were discharged; of 82 female patients, 7.3% (6/82) died and 86.6% (71/82) were discharged. Eleven laboratory parameters showed significant differences between male and female patients, and six of them were higher during the whole clinical course in patients who died than in patients who were discharged. In adjusted logistic regression analysis, males with comorbidities presented a higher risk of being critically ill than males without comorbidities (OR = 3.824, 95% CI = 1.279-11.435). However, this association attenuated to null in female patients (OR = 2.992, 95% CI = 0.937-9.558). A similar sex-specific trend was observed in the relation between age and critically ill conditions. We highlighted sex-specific differences in clinical characteristics and prognosis. Male patients appeared to be more susceptible to age and comorbidities. Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19.

摘要

目的: 在重症患者中证实性别与冠状病毒病-19 (新型冠状病毒肺炎) 进展的关系及其潜在机制。在这项回顾性研究中,我们纳入了中国武汉同济医院在 2020 年 1 月 16 日至 2 月 4 日期间住院的 168 例经病原体确诊的新型冠状病毒肺炎重症患者。比较分析男性和女性的临床特征、实验室参数和结局。在本研究中,我们分析了 168 例重症新型冠状病毒肺炎患者,其中男性 86 例,女性 82 例,48 例 (28.6%) 患者被诊断为危重症。86 例男性患者中,12.8% 例 (11/86) 死亡,75.6% 例 (65/86) 出院; 82 例女性患者中,7.3% 例 (6/82) 死亡,86.6% 例 (71/82) 出院。11 个实验室参数显示男女患者之间存在显著差异,其中 6 个在整个临床过程中死亡患者高于出院患者。在调整后的logistic回归分析中,有合并症的男性比无合并症的男性表现出更高的危重症风险 (OR = 3.824,95% CI = 1.279-11.435)。然而,这种相关性在女性患者中减弱至无效 (OR = 2.992,95% CI = 0.937-9.558)。在年龄和危重症之间的关系中观察到类似的性别特异性趋势。我们强调了临床特征和预后的性别特异性差异。男性患者似乎更容易受到年龄和合并症的影响。性别是新型冠状病毒肺炎防治中应考虑的重要生物学变量。

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翻译标题与摘要 下载文献
影响因子:2.48
发表时间:2020-04-01
来源期刊:Infection
DOI:10.1007/s15010-020-01401-y
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.

呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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