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Clinical characteristics of Kawasaki disease complicated with Mycoplasma pneumoniae pneumonia: A retrospective study.

川崎病合并支原体肺炎e肺炎的临床特点: 回顾性研究。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000019987
  • 作者列表:"Lan Y","Li S","Yang D","Zhou J","Wang Y","Wang J","Xu Y","Chen Z
  • 发表时间:2020-05-01
Abstract

:This study aimed to investigate the inner linkage and mechanism of Mycoplasma pneumoniae (MP) infection and Kawasaki disease (KD), as well as the risk factors of outcome in this cohort of patients.A retrospective study was performed in 210 patients diagnosed with KD complicated with community acquired pneumonia (CAP) in Children's Hospital, Zhejiang University School of Medicine from January 2014 to December 2017. They were divided into two groups based on MP infection: MP infection group (n = 97) and non-MP infection group (n = 113). We compared the variables of these two groups based on medical records.The MP infection group had higher ESR than the non-MP infection group. During hospitalization, the non-MP infection group had higher levels of WBC during hospital, LDH, PCT, and lower HB when compared to the MP infection group. No differences were found in the hs-CRP level, N%, PLT, ALT, CKMB, and cytokine levels (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) between MP and non-MP infection group. Likewise, no difference was found in fever duration or hospital stays between them. Totally 19 patients in the infection group had CAA with a rate of 19.59%; and 27 (23.89%) patients had CAA in the non-MP infection group. Unfortunately, no difference was found in CAA rate between the two groups.MP infection may occur simultaneously in children with Kawasaki disease. KD patients with MP infection tended to occur in older population. MP infection may not increase the risk of CAA, which still needs further large-scaled studies to confirm. Clinicians should be alert to KD patients with high level of ESR. MP should be screened and early treatment with macrolides should be given timely.

摘要

本研究旨在探讨肺炎支原体 (MP) 感染与川崎病 (KD) 的内在联系和机制,以及影响预后的危险因素。回顾性分析 210 例在儿童医院诊断为川崎病并发社区获得性肺炎肺炎的临床资料。浙江大学医学院 2014 年 1 月至 2017 年 12 月。根据MP感染情况分为MP感染组 (n = 97) 和非MP感染组 (n = 113)。我们根据病历比较了这两组的变量。MP感染组的ESR高于无MP感染组。住院期间,与非MP感染组相比,MP感染组住院期间WBC、LDH、PCT水平较高,HB水平较低。未发现hs-CRP水平、N % 、PLT、ALT、CKMB和细胞因子水平 (IL-2 、IL-4 、IL-6 、IL-10 、TNF-α 、和IFN-γ) 在MP和非MP感染组之间。同样,他们之间在发热持续时间或住院时间方面没有发现差异。感染组 19 例为CAA,发生率为 19.59%; 非MP感染组 27 例 (23.89%) 为CAA。不幸的是,两组之间的CAA率没有差异。小儿川崎病可同时发生MP感染。MP感染的KD患者往往发生在老年人群中。MP感染可能不会增加CAA的风险,仍需进一步大规模研究证实。临床医生应警惕高ESR水平的KD患者。应进行MP筛查,及时给予大环内酯类药物早期治疗。

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呼吸道感染方向

呼吸道感染分为上呼吸道感染与下呼吸道感染。上呼吸道感染是指自鼻腔至喉部之间的急性炎症的总称,是最常见的感染性疾病。下呼吸道感染是最常见的感染性疾患,治疗时必须明确引起感染的病原体以选择有效的抗生素。

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