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Evaluation of health-related quality of life using EQ-5D in China during the COVID-19 pandemic.


  • 影响因子:3.02
  • DOI:10.1371/journal.pone.0234850
  • 作者列表:"Ping W","Zheng J","Niu X","Guo C","Zhang J","Yang H","Shi Y
  • 发表时间:2020-06-18

OBJECTIVE:Since December 2019, an increasing number of cases of the 2019 novel coronavirus disease (COVID-19) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified in Wuhan, Hubei Province, China. Now, more cases have been reported in 200 other countries and regions. The pandemic disease not only affects physical health who suffered it, but also affects the mental health of the general population. This study aims to know about the impact of the COVID-19 epidemic on the health-related quality of life (HRQOL) of living using EQ-5D in general population in China. METHODS:An online-based survey was developed and participants were recruited via social media. The questionnaires included demographic and socioeconomic data, health status, the condition epidemic situation and EQ-5D scale. The relationships of all factors and the scores of EQ-5D were analyzed. Logistic regression model were used to the five health dimensions. RESULTS:The respondents obtained a mean EQ-5D index score of 0.949 and a mean VAS score of 85.52.The most frequently reported problem were pain/discomfort (19.0%) and anxiety/depression (17.6%). Logistic regression models showed that the risk of pain/discomfort and anxiety/depression among people with aging, with chronic disease, lower income, epidemic effects, worry about get COVID-19 raised significantly. CONCLUSION:The article provides important evidence on HRQOL during the COVID-19 pandemic. The risk of pain/discomfort and anxiety/depression in general population in China raised significantly with aging, with chronic disease, lower income, epidemic effects, worried about get COVID-19 during the COVID-19 pandemic. The results from each categorical data can be used for future healthcare measures among general population.


目的: 自 2019 年 12 月以来,湖北省武汉市发现 2019 例新型冠状病毒 (新型冠状病毒肺炎) 感染新型冠状病毒 (SARS-CoV-2) 病例。现在,其他 200 个国家和地区报告了更多的病例。这种大流行性疾病不仅影响患者的身体健康,而且影响普通人群的精神卫生。本研究旨在了解新型冠状病毒肺炎流行对中国普通人群使用EQ-5D生活的健康相关生活质量 (HRQOL) 的影响。 方法: 开发了基于在线的调查,并通过社交媒体招募参与者。调查问卷包括人口与社会经济数据、健康状况、病情流行情况和EQ-5D量表。分析各因子与EQ-5D得分的关系。对 5 个健康维度采用Logistic回归模型。 结果: 受访者的EQ-5D指数平均得分为 0.949,VAS平均得分为 85.52,最常报告的问题是疼痛/不适 (19.0%) 和焦虑/抑郁 (17.6%)。Logistic回归模型显示,老年、慢性病、低收入、流行病效应、担心get新型冠状病毒肺炎人群中,疼痛/不适和焦虑/抑郁的风险显著升高。 结论: 文章提供了新型冠状病毒肺炎大流行期间HRQOL的重要证据。随着年龄的增长,中国普通人群的疼痛/不适和焦虑/抑郁风险显著增加,慢性病、低收入、流行病影响、担心在新型冠状病毒肺炎大流行期间得到新型冠状病毒肺炎。每个分类数据的结果可用于未来普通人群的医疗保健措施。



作者列表:["Lim J","Jeon S","Shin HY","Kim MJ","Seong YM","Lee WJ","Choe KW","Kang YM","Lee B","Park SJ"]

METHODS::Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.

作者列表:["Zhang W","Du RH","Li B","Zheng XS","Yang XL","Hu B","Wang YY","Xiao GF","Yan B","Shi ZL","Zhou P"]

METHODS::In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.

翻译标题与摘要 下载文献
作者列表:["Cheng ZJ","Shan J"]

METHODS::There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days.