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Association between metabolic syndrome and knee structural change on MRI.

代谢综合征与MRI膝关节结构改变的相关性。

  • 影响因子:3.51
  • DOI:10.1093/rheumatology/kez266
  • 作者列表:"Pan F","Tian J","Mattap SM","Cicuttini F","Jones G
  • 发表时间:2020-01-01
Abstract

OBJECTIVE:To examine the association of metabolic syndrome (MetS) and its components with knee cartilage volume loss and bone marrow lesion (BML) change. METHODS:Longitudinal data on 435 participants from a population-based cohort study were analysed. Blood pressure, glucose, triglycerides and high-density lipoprotein (HDL) were collected. MetS was defined based on the National Cholesterol Education Program-Adult Treatment Panel III criteria. MRI of the right knee was performed to measure cartilage volume and BML. Radiographic knee OA was assessed by X-ray and graded using the Altman atlas for osteophytes and joint space narrowing. RESULTS:Thirty-two percent of participants had MetS and 60% had radiographic knee OA. In multivariable analysis, the following were independently associated with medial tibial cartilage volume loss: MetS, β = -0.30%; central obesity, β = -0.26%; and low HDL, β = -0.25% per annum. MetS, hypertriglyceridaemia and low HDL were also associated with higher risk of BML size increase in the medial compartment (MetS: relative risk 1.72, 95% CI 1.22, 2.43; hypertriglyceridaemia: relative risk 1.43, 95% CI 1.01, 2.02; low HDL: relative risk 1.67, 95% CI 1.18, 2.36). After further adjustment for central obesity or BMI, MetS and low HDL remained statistically significant for medial tibial cartilage volume loss and BML size increase. The number of components of MetS correlated with greater cartilage volume loss and BML size increase (both P for trend <0.05). There were no statistically significant associations in the lateral compartment. CONCLUSION:MetS and low HDL are associated with medial compartment cartilage volume loss and BML size increase, suggesting that targeting these factors has the potential to prevent or slow knee structural change.

摘要

目的: 探讨代谢综合征 (MetS) 及其组分与膝关节软骨体积丢失和骨髓病变 (BML) 的关系。 方法: 对一项基于人群的队列研究的 435 名参与者的纵向数据进行了分析。收集血压、血糖、甘油三酯和高密度脂蛋白 (HDL)。MetS是根据国家胆固醇教育项目-成人治疗小组III标准定义的。行右膝MRI检查,测量软骨体积和BML。通过x线评估x线片膝关节OA,并使用Altman图谱对骨赘和关节间隙狭窄进行分级。 结果: 32% 的参与者患有MetS,60% 患有放射学膝关节OA。在多变量分析中,以下因素与胫骨内侧软骨体积丢失独立相关: MetS,β = -0.30%; 中心性肥胖,β = -0.26%; 低HDL,Β = -0.25% 每年。MetS、高甘油三酯血症和低HDL也与内侧隔室BML大小增加的风险较高相关 (MetS: 相对风险 1.72,95% CI 1.22,2.43; 高甘油三酯血症: 相对风险 1.43,95% CI 1.01,2.02; 低HDL: 相对危险度 1.67,95% CI 1.18,2.36)。在进一步调整中心性肥胖或BMI后,MetS和低HDL对胫骨内侧软骨体积丢失和BML大小增加仍有统计学意义。MetS的成分数量与更大的软骨体积丢失和BML大小增加相关 (趋势均P <0.05)。外侧室无统计学显著相关性。 结论: MetS和低HDL与内侧间室软骨体积丢失和BML大小增加相关,提示靶向这些因子具有预防或减缓膝关节结构改变的潜力。

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

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发表时间:2020-01-01
DOI:10.1002/acr.23827
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