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Intraoral photobiomodulation diminishes pain and improves functioning in women with temporomandibular disorder: a randomized, sham-controlled, double-blind clinical trial : Intraoral photobiomodulation diminishes pain in women with temporomandibular disorder.

口腔内光生物调节可减轻颞下颌关节紊乱妇女的疼痛并改善功能: 一项随机、假对照、双盲临床试验: 口腔内光生物调节可减轻颞下颌关节紊乱妇女的疼痛。

  • 影响因子:2.32
  • DOI:10.1007/s10103-019-02841-1
  • 作者列表:"Herpich CM","Leal-Junior ECP","Politti F","de Paula Gomes CAF","Dos Santos Glória IP","de Souza Amaral MFR","Herpich G","de Azevedo LMA","de Oliveira Gonzalez T","Biasotto-Gonzalez DA
  • 发表时间:2020-03-01
Abstract

:The aim of the present study was to evaluate the effect of intraoral photobiomodulation involving super-pulsed laser (905 nm) combined with red (640 nm) and infrared (875 nm) light-emitting diodes on pain, mandibular range of motion, and functioning in women with myogenous temporomandibular disorder. A randomized, sham-controlled, double-blind clinical trial was conducted involving 30 women with myogenous temporomandibular disorder diagnosed using the Research Diagnostic Criteria for Temporomandibular Disorders. The participants were randomly allocated to two groups (active and sham photobiomodulation). The evaluations involved this use of the visual analog scale, digital calipers, and a functional scale. Photobiomodulation was administered intraorally in the region of the pterygoid muscles, bilaterally, in all participants for a total of six sessions. Evaluations were performed on five occasions: prior to the intervention, immediately after the first session, 24 h and 48 h after the first session, and after the six sessions. Significant differences between groups were found regarding pain (p ≤ 0.01) and functioning (p ≤ 0.04). However, no statistically significant difference was found regarding range of mandibular motion. The findings demonstrate that intraoral photobiomodulation involving super-pulsed laser (905 nm) combined with red (640 nm) and infrared (875 nm) light-emitting diodes diminishes pain and improves functioning but does not exert an influence on mandibular range of motion in women with temporomandibular disorder.Trial registration: NCT02839967.

摘要

: 本研究的目的是评估超脉冲激光 (905 nm) 结合红色 (640 nm) 和红外 (875 nm) 的口内光生物调制的效果。发光二极管对肌源性颞下颌关节紊乱妇女疼痛、下颌活动范围和功能的影响。采用颞下颌关节紊乱病研究诊断标准,对 30 例确诊为肌源性颞下颌关节紊乱病的妇女进行随机、假对照、双盲临床试验。参与者被随机分配到两组 (活性和假光生物调节)。评估涉及视觉模拟秤、数显卡尺和功能秤的使用。在所有参与者中,双侧翼肌区域经口内给予光生物调节,共 6 个疗程。进行了五次评价: 干预前、第一次治疗后 24 h和 48 h以及六次治疗后。组间疼痛 (p ≤ 0.01) 和功能 (p ≤ 0.04) 存在显著差异。然而,在下颌活动范围方面未发现统计学显著差异。研究结果表明,超脉冲激光 (905 nm) 结合红色 (640 nm) 和红外 (875 nm) 的口腔内光生物调节作用。发光二极管减轻疼痛,改善功能,但不影响颞下颌关节紊乱妇女的下颌活动范围。试用注册: nct02839967。

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METHODS:OBJECTIVE:Patients with immune-mediated inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus are at increased risk of cardiovascular disease. However, the cardiovascular risk of patients with primary Sjögren's syndrome (SS) remains poorly studied. We aimed to investigate the association between primary SS and cardiovascular morbidity and mortality. METHODS:We performed a systematic review of articles in Medline and the Cochrane Library and recent abstracts from US and European meetings, searching for reports of randomized controlled studies of cardiovascular morbidity and cardiovascular mortality in primary SS. The relative risk (RR) values for cardiovascular morbidity and mortality associated with primary SS were collected and pooled in a meta-analysis with a random-effects model by using Review Manager (Cochrane collaboration). RESULTS:The literature search revealed 484 articles and abstracts of interest; 14 studies (67,124 patients with primary SS) were included in the meta-analysis. With primary SS versus control populations, the risk was significantly increased for coronary morbidity (RR 1.34 [95% confidence interval (95% CI) 1.06-1.38]; P = 0.01), cerebrovascular morbidity (RR 1.46 [95% CI 1.43-1.49]; P < 0.00001), heart failure rate (odds ratio 2.54 [95% CI 1.30-4.97]; P < 0.007), and thromboembolic morbidity (RR 1.78 [95% CI 1.41-2.25]; P < 0.00001), with no statistically significant increased risk of cardiovascular mortality (RR 1.48 [95% CI 0.77-2.85]; P = 0.24). CONCLUSION:This meta-analysis demonstrates that primary SS is associated with increased cardiovascular morbidity, which suggests that these patients should be screened for cardiovascular comorbidities and considered for preventive interventions, in a multidisciplinary approach with cardiologists.

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23827
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