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One-Year Outcomes of Intraarticular Fat Transplantation for Thumb Carpometacarpal Joint Osteoarthritis: Case Review of 99 Joints.

关节内脂肪移植治疗拇指腕掌关节骨关节炎的一年结果: 99 个关节的病例回顾。

  • 影响因子:1.74
  • DOI:10.1097/PRS.0000000000006378
  • 作者列表:"Haas EM","Eisele A","Arnoldi A","Paolini M","Ehrl D","Volkmer E","Giunta RE
  • 发表时间:2020-01-01
Abstract

BACKGROUND:This study aims to present a new therapeutic option for the treatment of thumb carpometacarpal joint osteoarthritis. Knowing that autologous fat may be beneficial for osteoarthritis through antiinflammatory and chondroprotective effects, the authors transplanted autologous adipose fat into the thumb carpometacarpal joint with the objective of postponing definite resection arthroplasty surgery. METHODS:In this pilot study, the authors performed surgery on 99 joints. The study population consisted of patients with symptomatic and radiologically confirmed osteoarthritis of the thumb carpometacarpal joint. After harvesting abdominal adipose tissue, 1 to 2 ml of fat without physical or enzymatic manipulation were transplanted into the thumb carpometacarpal joint. Surgical outcome was quantified by use of the Michigan Hand Outcomes Questionnaire in addition to strength and pain measurements during a 12-month follow-up consultation. We conducted Friedman's analysis of variance to gauge the differences over time regarding Michigan Hand Outcomes Questionnaire and pain under stress. RESULTS:From 2 weeks on, there was pain relief, both under stress and at rest. Friedman's analysis of variance revealed a significant change in pain under stress [chi-square (5) = 68.52; p < 0.001]. Postoperative Michigan Hand Outcomes Questionnaire Scores improved significantly over 12 months [chi-square (5) = 90.56; p < 0.001]. CONCLUSION:The authors' preliminary findings suggest that intraarticular autologous fat transplantation is a promising alternative treatment of carpometacarpal joint osteoarthritis of the thumb. CLINICAL QUESTION/LEVEL OF EVIDENCE:Therapeutic, IV.

摘要

背景: 本研究旨在为拇指腕掌关节骨关节炎的治疗提供一种新的治疗选择。知道自体脂肪可能通过抗炎和软骨保护作用对骨关节炎有益,作者将自体脂肪脂肪移植到拇指腕掌关节,目的是推迟明确的切除关节成形术手术。 方法: 在这项初步研究中,作者对 99 个关节进行了手术。研究人群由症状和放射学证实的拇指腕掌关节骨关节炎患者组成。采集腹部脂肪组织后,将 1 ~ 2 ml未经物理或酶操作的脂肪移植到拇指腕掌关节。在 12 个月的随访咨询中,除了力量和疼痛测量外,还使用密歇根手结果问卷对手术结果进行量化。我们进行了Friedman的方差分析,以衡量密歇根手部结局问卷和压力下疼痛随时间的差异。 结果: 从 2 周开始,无论是在应激状态下还是在静息状态下,疼痛均有缓解。Friedman方差分析发现应激下疼痛有显著变化 [卡方 (5) = 68.5 2; p <0.001]。术后 12 个月密歇根手结局问卷评分显著改善 [卡方 (5) = 90.5 6; p <0.001]。 结论: 作者的初步研究结果表明,关节内自体脂肪移植是拇指腕掌关节骨关节炎的一种很有前途的替代治疗方法。 临床问题/证据水平: 治疗性,IV。

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发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

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发表时间:2020-01-01
DOI:10.1002/acr.23827
作者列表:["Lee RR","Rashid A","Thomson W","Cordingley L"]

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关节疾病方向

各类骨关节疾病,包括退行性关节炎、滑囊炎、滑膜炎、颈椎病、腰椎病、肩周炎、骨质增生、风湿性关节炎、类风湿性关节炎、股骨头坏死等。

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