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Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

比较萘普生和低剂量秋水仙碱治疗初级保健中痛风发作的开放标签随机实用性试验 (接触)。

  • 影响因子:9.18
  • DOI:10.1136/annrheumdis-2019-216154
  • 作者列表:"Roddy E","Clarkson K","Blagojevic-Bucknall M","Mehta R","Oppong R","Avery A","Hay EM","Heneghan C","Hartshorne L","Hooper J","Hughes G","Jowett S","Lewis M","Little P","McCartney K","Mahtani KR","Nunan D","Santer M","Williams S","Mallen CD
  • 发表时间:2020-02-01
Abstract

OBJECTIVES:To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. METHODS:This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general practices were randomised equally to naproxen 750 mg immediately then 250 mg every 8 hours for 7 days or low-dose colchicine 500 mcg three times per day for 4 days. The primary outcome was change in worst pain intensity in the last 24 hours (0-10 Numeric Rating Scale) from baseline measured daily over the first 7 days: mean change from baseline was compared between groups over days 1-7 by intention to treat. RESULTS:Between 29 January 2014 and 31 December 2015, we recruited 399 participants (naproxen n=200, colchicine n=199), of whom 349 (87.5%) completed primary outcome data at day 7. There was no significant between-group difference in average pain-change scores over days 1-7 (colchicine vs naproxen: mean difference -0.18; 95% CI -0.53 to 0.17; p=0.32). During days 1-7, diarrhoea (45.9% vs 20.0%; OR 3.31; 2.01 to 5.44) and headache (20.5% vs 10.7%; 1.92; 1.03 to 3.55) were more common in the colchicine group than the naproxen group but constipation was less common (4.8% vs 19.3%; 0.24; 0.11 to 0.54). CONCLUSION:We found no difference in pain intensity over 7 days between people with a gout flare randomised to either naproxen or low-dose colchicine. Naproxen caused fewer side effects supporting naproxen as first-line treatment for gout flares in primary care in the absence of contraindications. TRIAL REGISTRATION NUMBER:ISRCTN (69836939), clinicaltrials.gov (NCT01994226), EudraCT (2013-001354-95).

摘要

目的: 比较萘普生和低剂量秋水仙碱治疗初级保健痛风发作的有效性和安全性。 方法: 这是一项多中心开放标签随机试验。从 100 名全科医生中招募的痛风发作的成年人立即随机分配至萘普生 750 mg,然后每 8 小时 250 mg,持续 7 天,或低剂量秋水仙碱 500 mcg,每天三次,持续 4 次。几天。主要结局是过去 24 小时内最严重疼痛强度的变化 (0-1 0 数字评级量表),在前 7 天每天测量: 通过意向治疗比较 1-7 天组间从基线的平均变化。 结果: 在 29 年 1 月 20 1 4 和 3 1 年 12 月 20 1 5 之间,我们招募了 399 名参与者 (萘普生n = 200,秋水仙碱n = 1 99),其中 349 人 (87.5%) 第 7 天完成主要结局数据。第 1-7 天平均疼痛变化评分无显著组间差异 (秋水仙碱vs萘普生: 平均差异-0。1 8;95% CI -0.53 ~ 0.17; p = 0.32)。第 1-7 天,腹泻 (45.9% vs 20.0%; 或 3.3 1; 2.0 1 至 5.44) 和头痛 (20.5% vs 1 0.7%; 1.92; 1。03 ~ 3.55) 秋水仙碱组比萘普生组更常见,但便秘较少见 (4.8% vs 1 9.3%; 0.24; 0。1 1 至 0.54)。 结论: 我们发现随机接受萘普生或低剂量秋水仙碱治疗的痛风发作患者在 7 天内疼痛强度没有差异。萘普生在没有禁忌症的情况下,在初级保健中支持萘普生作为痛风发作的一线治疗的副作用较少。 试用注册号: ISRCTN (69836939),clinicaltrials.gov (NCT01994226),EudraCT (2013-001354-95)。

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METHODS:OBJECTIVE:Patients with immune-mediated inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus are at increased risk of cardiovascular disease. However, the cardiovascular risk of patients with primary Sjögren's syndrome (SS) remains poorly studied. We aimed to investigate the association between primary SS and cardiovascular morbidity and mortality. METHODS:We performed a systematic review of articles in Medline and the Cochrane Library and recent abstracts from US and European meetings, searching for reports of randomized controlled studies of cardiovascular morbidity and cardiovascular mortality in primary SS. The relative risk (RR) values for cardiovascular morbidity and mortality associated with primary SS were collected and pooled in a meta-analysis with a random-effects model by using Review Manager (Cochrane collaboration). RESULTS:The literature search revealed 484 articles and abstracts of interest; 14 studies (67,124 patients with primary SS) were included in the meta-analysis. With primary SS versus control populations, the risk was significantly increased for coronary morbidity (RR 1.34 [95% confidence interval (95% CI) 1.06-1.38]; P = 0.01), cerebrovascular morbidity (RR 1.46 [95% CI 1.43-1.49]; P < 0.00001), heart failure rate (odds ratio 2.54 [95% CI 1.30-4.97]; P < 0.007), and thromboembolic morbidity (RR 1.78 [95% CI 1.41-2.25]; P < 0.00001), with no statistically significant increased risk of cardiovascular mortality (RR 1.48 [95% CI 0.77-2.85]; P = 0.24). CONCLUSION:This meta-analysis demonstrates that primary SS is associated with increased cardiovascular morbidity, which suggests that these patients should be screened for cardiovascular comorbidities and considered for preventive interventions, in a multidisciplinary approach with cardiologists.

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

METHODS:OBJECTIVE:We aimed to evaluate the comparative risk of hospitalized infection among patients with rheumatoid arthritis (RA) who initiated abatacept versus a tumor necrosis factor inhibitor (TNFi). METHODS:Using claims data from Truven MarketScan database (2006-2015), we identified patients with RA ages ≥18 years with ≥2 RA diagnoses who initiated treatment with abatacept or a TNFi. The primary outcome was a composite end point of any hospitalized infection. Secondary outcomes included bacterial infection, herpes zoster, and infections affecting different organ systems. We performed 1:1 propensity score (PS) matching between the groups in order to control for baseline confounders. We estimated incidence rates (IRs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) for hospitalized infection. RESULTS:We identified 11,248 PS-matched pairs of patients who initiated treatment with abatacept and TNFi with a median age of 56 years (83% were women). The IR per 1,000 person-years for any hospitalized infection was 37 among patients who initiated treatment with abatacept and 47 in those who initiated treatment with TNFi. The HR for the risk of any hospitalized infection associated with abatacept versus TNFi was 0.78 (95% CI 0.64-0.95) and remained lower when compared to infliximab (HR 0.63 [95% CI 0.47-0.85]), while no significant difference was seen when compared to adalimumab and etanercept. The risk of secondary outcomes was lower for abatacept for pulmonary infections, and similar to TNFi for the remaining outcomes. CONCLUSION:In this large cohort of patients with RA who initiated treatment with abatacept or TNFi as a first- or second-line biologic agent, we found a lower risk of hospitalized infection after initiating abatacept versus TNFi, which was driven mostly by infliximab.

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23827
作者列表:["Lee RR","Rashid A","Thomson W","Cordingley L"]

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