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Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain.

芒果苷: 可能用于预防和治疗混合性骨关节痛。

  • 影响因子:3.62
  • DOI:10.1002/ptr.6546
  • 作者列表:"Garrido-Suárez BB","Garrido G","Piñeros O","Delgado-Hernández R
  • 发表时间:2020-03-01
Abstract

:Osteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as Mangifera indica L. Previous studies have documented its analgesic, anti-inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.

摘要

: 骨关节炎 (OA) 疼痛已被提出是一种混合性疼痛状态,因为在一些患者中,中枢神经系统因素叠加在更传统的外周因素上。此外,大量的临床前和临床证据表明,伴随着中枢神经可塑性变化,部分由外周伤害性输入驱动,真正的神经性成分发生,与疾病严重程度和进展特别相关。因此,可以引入针对神经保护,特别是神经炎症的创新策略来预防和治疗OA疼痛。芒果苷 (MG) 是一种葡萄糖基xanth酮,广泛分布于高等植物中,如芒果果。以前的研究已经记录了其镇痛,抗炎,抗氧化,神经保护和免疫调节特性。在本文中,我们提出其作为混合性OA疼痛的多靶点化合物的潜在效用,即使在多模式药物治疗的背景下。这一假设得到了三个主要方面的支持: 围绕这一黄酮的临床前证据的积云,在临床肌肉骨骼或神经性疼痛中使用含有MG的制剂的一些初步临床结果,并根据OA疼痛知识的最新进展推测其可能的作用机制。

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发表时间:2020-01-01
DOI:10.1002/acr.23824
作者列表:["Chen SK","Liao KP","Liu J","Kim SC"]

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影响因子:4.13
发表时间:2020-01-01
DOI:10.1002/acr.23827
作者列表:["Lee RR","Rashid A","Thomson W","Cordingley L"]

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关节疾病方向

各类骨关节疾病,包括退行性关节炎、滑囊炎、滑膜炎、颈椎病、腰椎病、肩周炎、骨质增生、风湿性关节炎、类风湿性关节炎、股骨头坏死等。

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