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Temozolomide plus whole brain radiotherapy for the treatment of non-small-cell lung cancer patients with brain metastases: A protocol of an updated systematic review and meta-analysis.

替莫唑胺联合全脑放疗治疗非小细胞肺癌脑转移患者: 一项更新的系统综述和荟萃分析方案。

  • 影响因子:1.95
  • DOI:10.1097/MD.0000000000018455
  • 作者列表:"Duan H","Zheng SY","Zhou T","Cui HJ","Hu KW
  • 发表时间:2020-01-01
Abstract

INTRODUCTION:Whole brain radiotherapy (WBRT) has been the mainstay treatment of brain metastases (BM) in non-small cell lung cancer (NSCLC) patients for years. Temozolomide (TMZ) could penetrate the blood-brain barrier and some studies showed that TMZ plus MBRT may improve clinical effectiveness. This meta-analysis is aim to evaluate the clinical effectiveness and safety of TMZ plus MBRT in the NSCLC patients with BM. METHODS AND ANALYSIS:We systematically searched databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and four Chinese databases (Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database) without language restrictions from inception until July 26, 2019. Randomized controlled trials (RCTs) which compared TMZ plus WBRT with single WBRT in the advanced NSCLC patients with BM were included. The outcomes analysis reported objective response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS), quality of life (QOL), and adverse effects. Two reviewers will independently extract data from the selected studies and assess the quality of studies. Statistical analyses will be performed using Review manager 5.3 software. Random-effects or fixed models were used to estimate pooled hazard ratio and relative risk. RESULTS:This systemic review and meta-analysis will evaluate the effects of TMZ plus MBRT in the NSCLC patients with BM in RCTs. CONCLUSION:Our study will provide evidence to judge if TMZ plus MBRT are effective treatment for NSCLC patients with BM.

摘要

引言: 全脑放疗 (WBRT) 多年来一直是非小细胞肺癌 (NSCLC) 患者脑转移 (BM) 的主要治疗方法。替莫唑胺 (TMZ) 可以穿透血脑屏障,一些研究表明TMZ加MBRT可以提高临床疗效。本荟萃分析旨在评估TMZ联合MBRT治疗合并BM的NSCLC患者的临床有效性和安全性。 方法和分析: 我们系统检索了包括PubMed、EMBASE、Cochrane中心对照试验注册数据库和四个中文数据库 (中文生物医学数据库、中国国家知识基础设施、万方数据库和中文科技期刊数据库) 自创刊至 2019 年 7 月 26 日无语言限制。纳入在BM晚期NSCLC患者中比较TMZ加WBRT与单一WBRT的随机对照试验 (rct)。结局分析报告客观缓解率 (ORR) 、疾病控制率 (DCR) 、总生存期 (OS) 、无进展生存期 (PFS) 、生活质量 (QOL) 、和不良反应。两名评价者将独立地从选定的研究中提取数据并评估研究的质量。将使用Review manager 5.3 软件进行统计分析。随机效应或固定模型用于估计合并风险比和相对风险。 结果: 本系统评价和荟萃分析将在RCTs中评价TMZ加MBRT在合并BM的NSCLC患者中的作用。 结论: 本研究将为TMZ联合MBRT治疗NSCLC合并BM患者的疗效判断提供依据。

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