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18F-FET PET for Diagnosis of Pseudoprogression of Brain Metastases in Patients With Non-Small Cell Lung Cancer.

18F-FET PET用于诊断非小细胞肺癌患者脑转移的假性进展。

  • 影响因子:1.51
  • DOI:10.1097/RLU.0000000000002890
  • 作者列表:"Akhoundova D","Hiltbrunner S","Mader C","Förster R","Kraft J","Schwanhäusser B","Bankel L","Kollias S","Treyer V","Rushing EJ","Lee SY","Andratschke N","Hüllner M","Curioni-Fontecedro A
  • 发表时间:2020-02-01
Abstract

PURPOSE:To evaluate whether F-fluoroethyltyrosine (FET) PET can discriminate progression from pseudoprogression of brain metastases in patients with non-small cell lung cancer undergoing immunotherapy and radiotherapy to the brain. METHODS:Retrospective analysis of F-FET PET scans in cases with documented progression of brain metastases on MRI in a cohort of 53 patients with non-small cell lung cancer receiving immune-checkpoint inhibitors and radiotherapy of brain metastases at the University Hospital of Zürich from June 2015 until January 2019. Response to radiotherapy was assessed by MRI. In case of equivocal findings and/or radiological progression in clinically asymptomatic patients, further assessment with F-FET PET was performed. RESULTS:From the cohort of 53 patients, the restaging MRI showed in 30 patients (56.6%) progression of at least 1 treated metastasis. Thereof, F-FET PET was performed in 11 patients, based on the absence of neurological symptoms or presence of systemic response and physicians' decision. F-FET PET correctly identified pseudoprogression in 9 of 11 patients (81.8%). In patients who did not undergo F-FET PET, 5 of 19 (26.3%) were diagnosed with pseudoprogression. CONCLUSIONS:Pseudoprogression of brain metastases occurred in 50% of patients diagnosed with progression on MRI. F-FET PET may help differentiate pseudoprogression from real progression in order to avoid discontinuation of effective therapy or unneeded interventions.

摘要

目的: 评估F-氟乙基酪氨酸 (FET) PET能否区分接受脑免疫治疗和放疗的非小细胞肺癌患者脑转移的进展和假性进展。 方法: 对 53 例接受免疫检查点抑制剂和脑放疗的非小细胞肺癌患者的MRI显示脑转移进展病例进行f-fet PET扫描的回顾性分析 2015 年 6 月至 2019 年 1 月在苏黎世大学医院的转移。通过MRI评估对放疗的反应。在临床无症状患者中出现模棱两可的发现和/或放射学进展的情况下,用F-FET PET进行进一步评估。 结果: 在 53 例患者的队列中,复查MRI显示 30 例患者 (56.6%) 至少 1 个治疗转移的进展。其中,F-fetpet在 11 名患者中进行,基于没有神经症状或存在全身反应和医生的决定。F-fet PET在 11 例患者中的 9 例 (81.8%) 中正确识别出假性进展。在未接受f-fet PET的患者中,19 例患者中有 5 例 (26.3%) 被诊断为假性进展。 结论: 在MRI诊断为脑转移进展的患者中,50% 发生假性进展。F-fetpet可有助于区分假性进展与真实进展,以避免停止有效治疗或不必要的干预。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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影响因子:6.93
发表时间:2020-01-01
DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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