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Impact of CCL4 gene polymorphisms upon the progression of lung cancer in a Han Chinese cohort.

CCL4 基因多态性对中国汉族人群肺癌进展的影响.

  • 影响因子:0
  • DOI:10.1097/MD.0000000000018906
  • 作者列表:"Hu W","Chien SY","Ying P","Liu PI","Su CM","Tang CH
  • 发表时间:2020-01-01
Abstract

:Lung cancer is the most common malignancy in China and has a low survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatment. Chemokine (C-C motif) ligand 4 (CCL4) plays a critical role as a chemoattractant in tumor development, metastasis and angiogenesis. In this study, we explored three CCL4 single nucleotide polymorphisms (SNPs) (rs1634507, rs1719153, and rs10491121) in 538 patients with lung cancer and 370 healthy, cancer-free controls. Carriers of the GT + TT heterozygote of rs1634507 had a lower risk of lung cancer than wild-type (GG) carriers, while the presence of the AG + GG heterozygote at rs10491121 was associated with a higher risk of lung cancer compared with having the AA genotype. The G/A/G and T/A/A CCL4 haplotypes significantly reduced and increased the risks for lung cancer, respectively. Our study is the first to document correlations between CCL4 polymorphisms and lung cancer development and progression in people of Han Chinese ethnicity.

摘要

肺癌是中国最常见的恶性肿瘤,在中国汉族中生存率低。高死亡率很大程度上归因于晚期诊断,此时治疗基本无效。基因变异的鉴定可能有助于早期诊断,从而更有效的治疗。趋化因子 (c-c基序) 配体 4 (CCL4) 在肿瘤发展、转移和血管生成中起着重要的化学引诱剂作用。在这项研究中,我们在 538 例肺癌患者和 370 例健康无癌对照中探索了三个CCL4 单核苷酸多态性 (snp) (rs1634507 、rs1719153 和rs10491121)。Rs1634507 的GT + TT杂合子携带者患肺癌的风险低于野生型 (GG) 携带者,而rs10491121 的AG + GG杂合子的存在与具有AA基因型相比具有更高的肺癌风险相关。G/A/G和T/A CCL4 单倍型分别显著降低和增加肺癌的风险。本研究首次证实了CCL4 基因多态性与中国汉族人群肺癌发生发展的相关性。

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影响因子:6.93
发表时间:2020-01-15
DOI:10.1002/ijc.32532
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影响因子:6.93
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DOI:10.1002/ijc.32530
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肺肿瘤方向

肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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