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Diagnostic imaging of typical lung carcinoids: relationship between MDCT, 111In-Octreoscan and 18F-FDG-PET imaging features with Ki-67 index.

典型肺类癌的诊断成像: MDCT、 111in-奥曲肽oscan和 18F-FDG-PET成像特征与Ki-67 指数的关系。

  • 影响因子:0
  • DOI:10.1007/s11547-020-01172-4
  • 作者列表:"Danti G","Berti V","Abenavoli E","Briganti V","Linguanti F","Mungai F","Pradella S","Miele V
  • 发表时间:2020-08-01
Abstract

AIMS:This study analyses the capability of contrast-enhanced multi-detector computed tomography (MDCT) and spectrum of molecular imaging to characterize typical carcinoids (TCs) of lung and their relationship with Ki-67 index. MATERIALS AND METHODS:We analysed 68 patients with histological diagnosis of pulmonary TC, which underwent both MDCT and nuclear molecular imaging (somatostatin receptor scintigraphy/SPECT with 111In-pentetreotide and 18F-FDG-PET/CT) at staging evaluation before surgery. The MDCT scan was reviewed for the following features: size, margins, contrast enhancement, presence of calcifications, bronchial obstruction, lymph nodes and metastases. In 111In-pentetreotide SPECT, tumour/non-tumour ratio was measured at 4- and 24-h post-injection and the per cent difference was calculated (T/NT%). FDG uptake was measured as the ratio between lesion SUVmax and liver SUVmean (SUV ratio). All imaging features were correlated between them and with Ki-67 index. RESULTS:Forty-four of the 68 lesions (65%) were in the right lung. In MDCT, scan lesions appeared as a well-defined nodule in 44 patients (65%) and irregular mass in 24 patients (35%). Contrast intense enhancement was present in 53 patients (78%), calcifications in 20 patients (29%) and bronchial obstruction in 24 patients (35%). Lymph nodes and metastasis were present in 13 (19%) and 15 (22%) patients. Ki-67 index was negatively correlated with T/NT% and positively with SUV ratio; T/NT% and SUV ratio were inversely correlated. The presence of irregular margins and metastases was negatively related to T/NT%. The presence of a mass, irregular margins, bronchial obstruction, lymph nodes and metastasis was positively related to higher SUV ratio. The presence of irregular margins, bronchial obstruction, lymph nodes and metastases was significantly correlated with a higher grade of Ki-67 index. CONCLUSIONS:MDCT and nuclear molecular imaging are important to characterize lung TCs. The majority of TCs appear as a well-defined nodule generally not associated with extra-thorax signs. We found a significant correlation between some MDCT aspects, nuclear medicine features and Ki-67 index. The association of MDCT and nuclear medicine imaging may be useful in predicting proliferative activity and prognosis of lung TCs.

摘要

目的: 本研究分析对比增强多排螺旋ct (MDCT) 和分子影像谱表征肺典型类癌 (TCs) 的能力及其与Ki-67 指数的关系。 材料和方法: 我们分析了 68 例组织学诊断为肺TC的患者,这些患者同时接受了MDCT和核分子显像 (生长抑素受体显像/SPECT联合 111In-pentetreotide和 18F-FDG-PET/CT) 术前分期评估。回顾MDCT扫描的以下特征: 大小,边缘,对比增强,钙化的存在,支气管阻塞,淋巴结和转移。在 111In-pentetreotide SPECT中,在注射后 4 小时和 24 小时测量肿瘤/非肿瘤比率,并计算百分比差异 (T/NT %)。FDG摄取被测量为病灶SUVmax和肝脏SUVmean之间的比率 (SUV比率)。所有成像特征之间具有相关性,并且具有Ki-67 指数。 结果: 68 个病灶中有 44 个病灶 (65%) 位于右肺。在MDCT中,44 例患者 (65%) 的扫描病灶表现为明确的结节,24 例患者 (35%) 的不规则肿块。对比强增强 53 例 (78%),钙化 20 例 (29%),支气管阻塞 24 例 (35%)。13 例 (19%) 和 15 例 (22%) 患者有淋巴结转移。Ki-67 指数与T/NT % 呈负相关,与SUV比值呈正相关; T/NT % 与SUV比值呈负相关。不规则边缘和转移的存在与T/NT % 呈负相关。肿块、不规则边缘、支气管阻塞、淋巴结和转移的存在与较高的SUV比率正相关。不规则边缘、支气管阻塞、淋巴结和转移的存在与Ki-67 指数的较高级别显著相关。 结论: MDCT和核分子成像对肺TCs的特征是重要的。大多数TCs表现为明确的结节,通常与胸外体征无关。我们发现一些MDCT方面、核医学特征和Ki-67 指数之间存在显著相关性。MDCT与核医学成像的相关性可能有助于预测肺TCs的增殖活性和预后。

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DOI:10.1002/ijc.32532
作者列表:["Hata A","Nakajima T","Matsusaka K","Fukuyo M","Morimoto J","Yamamoto T","Sakairi Y","Rahmutulla B","Ota S","Wada H","Suzuki H","Matsubara H","Yoshino I","Kaneda A"]

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DOI:10.1002/ijc.32530
作者列表:["Zhang L","Yang Y","Chai L","Bu H","Yang Y","Huang H","Ran J","Zhu Y","Li L","Chen F","Li W"]

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肺肿瘤,又叫支气管肺癌,是常见的恶性肿瘤之一。肺肿瘤的治疗为包括手术、中药、放疗、化疗及免疫等多学科的综合治疗。

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