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Cumulative HIV viremia copy-years and hypertension in people living with HIV.

HIV 感染者的累积 HIV 病毒血症拷贝-年和高血压。

  • 影响因子:1.09
  • DOI:10.2174/1570162X18666200131122206
  • 作者列表:"Xu Y","Chen X","Wijayabahu A","Zhou Z","Yu B","Spencer EC","Cook RL
  • 发表时间:2020-01-31
Abstract

BACKGROUND:Evidence regarding the association between HIV viral load (VL) and hypertension is inconsistent. In this study, we investigated the relationship using viremia copy-years (VCY), a cumulative measure of HIV plasma viral burden.,METHODS:Data were analyzed for 686 PLWH in the Florida Cohort Study who had at least five years of VL data before the baseline. VL data were extracted from Enhanced HIV/AIDS Reporting System (eHARS) and used to define peak VL (pVL), recent VL (rVL), and undetectable VL (uVL: rVL<50copies/mL). A five-year VCY (log10 copy × years/mL) before the baseline investigation was calculated and divided into 5 groups (<2.7, 2.7-3.7. 3.8-4.7, 4.8-5.7 and >5.7) for analysis. Hypertension was determined based on hypertension diagnosis from medical records. Multivariable logistic regression was used for association analysis.,RESULTS:Of the total sample, 277 (40.4%) participants were hypertensive. Compared to the participants with lowest VCY (<2.7 log10 copy × years/mL), the odds ratios (OR) and 95% confidence interval [95% CI] for hypertension of the remaining four groups, in order, were 1.91 [1.11, 3.29], 1.91 [1.03, 3.53], 2.27 [1.29, 3.99], and 1.25 [0.65, 2.42], respectively, controlling for confounders. The association was independent of pVL, rVL, and uVL, each of which was not statistically significant associations with hypertension.,CONCLUSION:Persistent HIV infection is a risk factor for hypertension among PLWH. Information provided by VCY is more effective than single time-point VL measures in investigating HIV infection-hypertension relationship. Findings of this study support the significance of continuous viral suppression in hypertension prevention among PLWH.

摘要

背景: 关于 HIV 病毒载量 (VL) 和高血压之间关系的证据是不一致的。在这项研究中,我们使用病毒血症拷贝-年 (VCY) 调查关系,VCY 是 HIV 血浆病毒负担的累积测量。,方法: 对佛罗里达队列研究中 686 例 PLWH 的数据进行了分析,该研究在基线前至少有 5 年的 VL 数据。从增强型艾滋病毒/艾滋病报告系统 (eHARS) 中提取 VL 数据,用于定义峰值 VL (pVL) 、近期 VL (rVL) 和不可检测的 VL (uVL: rVL<50 拷贝/mL)。计算基线调查前 5 年 VCY (log10 拷贝 × 年/mL),分为 5 组 (<2.7,2.7-3.7。3.8-4.7 、 4.8-5.7 和> 5.7) 进行分析。根据病历的高血压诊断确定高血压。使用多变量 logistic 回归进行关联分析。结果: 在总样本中,277 (40.4%) 参与者患有高血压。与 VCY 最低 (<2.7 log10 拷贝 × 年/mL) 的参与者相比,其余四组高血压的比值比 (OR) 和 95% 置信区间 [95% CI],依次为 1.91 [1.11,3.29],1.91 [1.03,3.53],2.27 [1.29,3.99],和 1.25 [0.65,2.42],分别控制混杂因素。该相关性独立于 pVL 、 rVL 和 uVL,三者与高血压的相关性无统计学意义。结论: 在 PLWH 中,HIV 持续感染是高血压的危险因素。VCY 提供的信息在调查 HIV 感染-高血压关系方面比单一时间点 VL 措施更有效。本研究结果支持持续病毒抑制在 PLWH 高血压预防中的意义。

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