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The value of serum Krebs von den lungen-6 as a diagnostic marker in connective tissue disease associated with interstitial lung disease

血清 Krebs-von-den lungen-6 在结缔组织病合并间质性肺病诊断中的价值

  • 影响因子:2.40
  • DOI:10.1186/s12890-019-1043-z
  • 作者列表:"Hua Ma","Junhui Lu","Yuanyuan Song","Huixuan Wang","Songlou Yin
  • 发表时间:2020-01-12
Abstract

Abstract Objectives The purpose of this study was to evaluate the value of serum krebs von den lungen-6 (KL-6) level as a diagnostic indicator for connective tissue disease associated with interstitial lung disease (CTD-ILD). Methods One hundred fifty five patients with newly diagnosed CTD in our hospital were enrolled and divided into two groups by their ILD manifestations, the CTD-ILD group and the CTD group. In parallel, 61 patients with pulmonary infection and 60 cases of healthy subjects were also enrolled into the study. The difference of serum KL-6 level among the four groups were compared. In CTD-ILD group, carbon monoxide diffusing capacity (DLCo) and high-resolution computed tomography (HRCT) of lung were also tested. The serum KL-6 level of 32 patients from the CTD-ILD group who received cyclophosphamide (CTX) pulse therapy were sampled and measured, by enzyme linked immunosorbent assay (ELISA), at three time points: before treatment, 3 months after treatment and 6 months after treatment. Results The serum KL-6 level in the CTD-ILD group (1004.9 (676.41738.1) IU/ml) is significantly higher than three other groups (χ 2  = 72.29, P  < 0.001). In the CTD-ILD group the level of serum KL-6 was positively correlated with disease severity on HRCT (r = 0.75, P < 0.001), while was negatively correlated with DLCo (r = − 0.50, P < 0.001). In 32 patients who received CTX pulse therapy, the level of serum KL-6 was gradually decreased in 20 cases whose lesions were absorbed within 6 months (F = 13.67, P < 0.001), whereas it remained unchanged in the rest of 12 patients (Z = -1.328, P = 0.198). Conclusions: Serum KL-6 level can potentially serve as a diagnostic marker for CTD-ILD and be utilized to evaluate the effectiveness of CTX pulse therapy. Keywords: Connective tissue disease, Interstitial lung disease, Connective tissue disease associated with interstitial lung disease, Krebs von den lungen-6

摘要

摘要: 目的: 本研究的目的是评估血清 krebs von den lungen-6 (KL-6) 的价值。水平作为间质性肺病 (CTD-ILD) 相关结缔组织病的诊断指标。方法选择我院初诊 CTD 患者 55 例,根据其 ILD 表现分为 CTD-ILD 组和 CTD 组。同时,61 例肺部感染患者和 60 例健康受试者也被纳入研究。比较四组血清 KL-6 水平的差异。CTD-ILD 组同时进行一氧化碳弥散量 (DLCo) 和肺高分辨率计算机断层扫描 (HRCT) 检查。采用酶联免疫吸附试验 (ELISA) 对 32 例接受环磷酰胺 (CTX) 冲击治疗的 CTD-ILD 患者的血清 KL-6 进行采样,测定三个时间点: 治疗前、治疗后 3 个月、治疗后 6 个月。结果 CTD-ILD 组血清 KL-6 (1004.9 (676.41738.1) IU/ml) 明显高于其他 3 组 (χ 2 = 72.29,p

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影响因子:4.40
发表时间:2020-01-01
DOI:10.1007/s00262-019-02431-8
作者列表:["Shibaki, Ryota","Murakami, Shuji","Matsumoto, Yuji","Yoshida, Tatsuya","Goto, Yasushi","Kanda, Shintaro","Horinouchi, Hidehito","Fujiwara, Yutaka","Yamamoto, Nobuyuki","Kusumoto, Masahiko","Yamamoto, Noboru","Ohe, Yuichiro"]

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翻译标题与摘要 下载文献
影响因子:4.04
发表时间:2020-01-25
来源期刊:New biotechnology
DOI:10.1016/j.nbt.2019.08.006
作者列表:["Sousa SA","Soares-Castro P","Seixas AMM","Feliciano JR","Balugas B","Barreto C","Pereira L","Santos PM","Leitão JH"]

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