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Assessment of interstitial lung disease in systemic sclerosis using the quantitative CT algorithm CALIPER.

使用定量 CT 算法卡尺评估系统性硬化症的间质性肺疾病。

  • 影响因子:2.26
  • DOI:10.1007/s10067-020-04938-3
  • 作者列表:"Ferrazza AM","Gigante A","Gasperini ML","Ammendola RM","Paone G","Carbone I","Rosato E
  • 发表时间:2020-01-15
Abstract

:Interstitial lung disease (ILD) remains a major cause of morbidity and mortality in systemic sclerosis (SSc). Study aim is to characterize and quantify SSc-ILD by using Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER). Secondly, our objective is to evaluate which radiological pattern is predictive of lung function decline at 12 months follow-up. In the prospective study (IRB 5435), 66 SSc patients underwent high-resolution computerized tomography (HRCT) at baseline. HRCT was performed according to standard protocol using a CT 64GE light speed VCT power scanner. CALIPER classified lung parenchyma on volume units. Every volume unit was classified into radiological parenchymal patterns (honeycombing, reticular and ground glass). Pulmonary function tests (PFTs) were performed at baseline and after 12 months of follow-up. Cigarette smoking and other lung diseases unrelated to SSc are exclusion criteria. CALIPER analysis showed normal lung parenchyma 87.4 ± 9.8%, ground glass 2.8 ± 5.3%, reticular 4 ± 5.7%, and honeycombing 1 ± 1%. In multiple regression analysis, FEV1 (p < 0.0001), FVC (p = 0.001), and DLCO (p < 0.0001) measurements at baseline showed a negative correlation with the reticular pattern percentage. At follow-up, DLCO reduction showed a positive correlation (p < 0.001) with the percentage of ground glass pattern (r = 0.33, beta coefficient = 0.51). In the ROC curve analysis, ground glass score is a good predictor (0.75, p = 0.009; 95% CI 0.59–0.91) of DLCO worsening, defined as a decrease of more than 10% of DLCO. Using a cutoff ≥ 4.5 for ground glass score, the RR for DLCO worsening is 6.8 (p < 0.01; 95% CI 1.6–29.2). The results of this study show that CALIPER is useful not only for quantifying lung damage but also for assessing worsening PFTs, but larger studies are needed to confirm these preliminary data.

摘要

间质性肺病 (ILD) 仍然是系统性硬化症 (SSc) 发病和死亡的主要原因。研究目的是通过使用计算机辅助肺信息学进行病理学评价和评级 (卡尺) 来描述和量化 SSc-ILD。其次,我们的目的是在 12 个月随访时评估哪种放射学模式可预测肺功能下降。在前瞻性研究 (IRB 5435) 中,66 例 SSc 患者在基线时接受了高分辨率计算机断层扫描 (HRCT)。根据标准方案,使用 CT 64GE 光速 VCT 功率扫描仪进行 HRCT 检查。卡尺分类肺实质上的体积单位。将每个体积单位分为放射性实质模式 (蜂窝状、网状和磨玻璃)。在基线和随访 12 个月后进行肺功能检查 (PFTs)。吸烟和其他与 SSc 无关的肺部疾病为排除标准。卡尺分析显示正常肺实质 87.4 ± 9.8%,磨玻璃 2.8 ± 5.3%,网状 4 ± 5.7%,蜂窝 1 ± 1%。在多元回归分析中,基线时 FEV1 (p

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影响因子:4.40
发表时间:2020-01-01
DOI:10.1007/s00262-019-02431-8
作者列表:["Shibaki, Ryota","Murakami, Shuji","Matsumoto, Yuji","Yoshida, Tatsuya","Goto, Yasushi","Kanda, Shintaro","Horinouchi, Hidehito","Fujiwara, Yutaka","Yamamoto, Nobuyuki","Kusumoto, Masahiko","Yamamoto, Noboru","Ohe, Yuichiro"]

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翻译标题与摘要 下载文献
影响因子:4.04
发表时间:2020-01-25
来源期刊:New biotechnology
DOI:10.1016/j.nbt.2019.08.006
作者列表:["Sousa SA","Soares-Castro P","Seixas AMM","Feliciano JR","Balugas B","Barreto C","Pereira L","Santos PM","Leitão JH"]

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