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Airway wall thickness and airflow limitations in asthma assessed in quantitative computed tomography.

定量计算机断层扫描评估哮喘的气道壁厚度和气流受限。

  • 影响因子:2.93
  • DOI:10.1177/1753466619898598
  • 作者列表:"Patyk M","Obojski A","Sokołowska-Dąbek D","Parkitna-Patyk M","Zaleska-Dorobisz U
  • 发表时间:2020-01-01
Abstract

BACKGROUND:Asthma is a frequent chronic disease of the airways. In spite of the fact that symptoms of asthma are well known, the pathogenesis has not yet been fully understood. Quantitative computed tomography (qCT) of the lung allows for the measurment of a set of parameters. The aim of this study was to evaluate the usefulness of quantitative computed tomography in the assessment of airway wall thickness in asthma. METHODS:The prospective study was performed on a group of 83 patients with well-defined, long-term asthma between 2016 and 2018. The control group was composed of 30 healthy volunteers. All examined subjects were non-smokers. All computed tomography (CT) studies were performed using a 128 multi-slice CT scanner with no contrast, following a chest scanning protocol in the supine position, at full inspiration and breath-holds. RESULTS:Quantitative bronchial tree measurements were obtained from the third up to the ninth generation of the posterior basal bronchi (B10) of the right lung in a blinded fashion. The value of the wall thickness in patients with asthma was significantly higher in all measured generations of the bronchial tree (third to ninth generation). The lumen area and the inner diameter significantly correlated with the lung function tests and were substantially smaller in the examined group from the seventh to the ninth generation of the bronchi (p < 0.05). Conclusions: We conclude that airway remodelling occurs in most patients with long-term asthma and is associated mainly with the medium and small airways. Imaging techniques, especially qCT can be useful in the diagnosis and management of asthma.

摘要

背景: 哮喘是一种常见的气道慢性疾病。尽管哮喘的症状是众所周知的,但发病机制尚未完全清楚。肺定量计算机断层扫描 (qCT) 允许测量一组参数。本研究的目的是评估定量计算机断层扫描在哮喘气道壁厚度评估中的有效性。 方法: 前瞻性研究是在 2018 和 2016年对 83 例明确定义的长期哮喘患者进行的。对照组由 30 名健康志愿者组成。所有受检对象均为不吸烟者。所有计算机断层扫描 (CT) 研究均使用无对比度的 128 多层 CT 扫描仪进行,遵循仰卧位、充分吸气和屏气的胸部扫描方案。 结果: 以盲法获得右肺后基底支气管 (B10) 第三代至第九代的定量支气管树测量。在支气管树的所有测量代 (第三至第九代) 中,哮喘患者的壁厚值显著较高。管腔面积和内径与肺功能检查显著相关,在第七代至第九代支气管的受检者中显著较小 (p <0.05)。 结论: 我们得出结论,气道重塑发生在大多数长期哮喘患者中,主要与中小气道相关。成像技术,尤其是 qCT 可用于哮喘的诊断和治疗。

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影响因子:3.31
发表时间:2020-01-02
DOI:10.1007/s10916-019-1481-4
作者列表:["Matava, Clyde","Pankiv, Evelina","Raisbeck, Sam","Caldeira, Monica","Alam, Fahad"]

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影响因子:3.84
发表时间:2020-01-01
来源期刊:Chest
DOI:10.1016/j.chest.2019.06.018
作者列表:["Dhooria S","Chaudhary S","Ram B","Sehgal IS","Muthu V","Prasad KT","Aggarwal AN","Agarwal R"]

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