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A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137.

一种来自海洋来源的疣状孢子菌的具有抗甲型流感病毒活性的新型深海霉素聚酮。ms100137

  • 影响因子:3.92
  • DOI:10.1007/s00253-019-10217-2
  • 作者列表:"Zhang J","Li B","Qin Y","Karthik L","Zhu G","Hou C","Jiang L","Liu M","Ye X","Liu M","Hsiang T","Dai H","Zhang L","Liu X
  • 发表时间:2020-02-01
Abstract

:Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine Verrucosispora sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (1), together with six known abyssomicin and proximicin analogs (2-7). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds 1-3 showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than 4. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.

摘要

: 海洋微生物生活在截然不同的环境中,因其结构独特、具有潜在强生物活性的天然产物而备受关注。基于一株多化合物 (OSMAC) 策略和液相色谱质谱 (LC-MS) 方法,我们继续努力研究海洋疣状孢子菌的新型活性化合物。 MS100137 已经鉴定出一种新的多环代谢物,abyssomicin Y (1),以及六种已知的 abyssomicin 和 proximicin 类似物(2-7)。深新星 Y 是一种 I 型深新星,环氧化物基团在 C-8 和 C-9。化合物 1-3 对甲型流感病毒表现出强效的抑制作用; 在 10 μ m 浓度下,它们的观察抑制率分别为 97.9% 、 98.3% 和 95.9%, 它们表现出比 4 更低的细胞毒性。通过不同的 NMR 技术和 HRMS 实验确定了其结构。本研究揭示了 OSMAC 可以作为一种有用的方法,使微生物中的沉默基因能够激活,并形成以前未报道的活性次级代谢产物。

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影响因子:5.31
发表时间:2020-01-19
DOI:10.1093/cid/ciaa050
作者列表:["Baum U","Kulathinal S","Auranen K","Nohynek H"]

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影响因子:1.36
发表时间:2020-01-20
DOI:10.1111/1348-0421.12775
作者列表:["Ainai A","van Riet E","Ito R","Ikeda K","Senchi K","Suzuki T","Tamura SI","Asanuma H","Odagiri T","Tashiro M","Kurata T","Multihartina P","Setiawaty V","Andriana Pangesti KN","Hasegawa H"]

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影响因子:6.53
发表时间:2020-01-21
DOI:10.1016/S1473-3099(19)30584-5
作者列表:["Liebowitz D","Gottlieb K","Kolhatkar NS","Garg SJ","Asher JM","Nazareno J","Kim K","McIIwain DR","Tucker SN"]

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