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Effects of baseline heart rate at sea level on cardiac responses to high-altitude exposure.

海平面基线心率对高原暴露心脏反应的影响。

  • 影响因子:1.76
  • DOI:10.1007/s10554-020-01769-w
  • 作者列表:"Tian J","Liu C","Yang Y","Yu S","Yang J","Zhang J","Ding X","Zhang C","Rao R","Zhao X","Huang L
  • 发表时间:2020-05-01
Abstract

:High-altitude (HA) exposure has been widely considered as a cardiac stress, and associated with altered cardiac function. However, the characteristics of cardiac responses to HA exposure are unclear. In total, 240 healthy men were enrolled and ascended to 4100 m by bus within 7 days. Standard echocardiography and color tissue Doppler imaging were performed at sea level and at 4100 m. In all subjects, HA exposure increased HR [65 (59, 71) vs. 72 (63, 80) beats/min, p < 0.001] but decreased the stroke volume index (SVi) [35.5 (30.5, 42.3) vs. 32.9 (27.4, 39.5) ml/m2, p < 0.001], leading to an unchanged cardiac index (CI). Moreover, baseline HR was negatively correlated with HA exposure-induced changes in HR (r = - 0.410, p < 0.001) and CI (r = - 0.314, p < 0.001). Following HA exposure, subjects with lowest tertile of baseline HR showed an increased HR [56 (53, 58) vs. 65 (58, 73) beats/min, p < 0.001], left ventricular ejection fraction (LVEF) [61.7 (56.5, 68.0) vs. 66.1 (60.7, 71.5) %, p = 0.004] and mitral S' velocity [5.8 ± 1.4 vs. 6.5 ± 1.9 cm/s, p = 0.040]. However, subjects with highest tertile of baseline HR showed an unchanged HR, LVEF and mitral S' velocity, but a decreased E' velocity [9.2 ± 2.0 vs. 8.4 ± 1.8 cm/s, p = 0.003]. Our findings indicate that baseline HR at sea level could determine cardiac responses to HA exposure; these responses were characterized by enhanced LV function in subjects with a low baseline HR and by reduced LV myocardial velocity in early diastole in subjects with a high baseline HR.

摘要

: 高海拔 (HA) 暴露被广泛认为是一种心脏应激,并与心脏功能改变有关。然而,心脏对HA暴露的反应特征尚不清楚。共纳入240例健康男性,7天内乘公交车上升至4100 m。在海平面和4100米处进行标准超声心动图和彩色组织多普勒成像。在所有受试者中,HA暴露增加HR [65 (59,71) vs. 72 (63,80) 次/分,p  <  0.001] 但降低了每搏输出量指数 (SVi) [35.5 (30.5,42.3)对32.9 (27.4,39.5) ml/m2,p <0.001],导致心脏指数 (CI) 不变。此外,基线HR与HA暴露引起的HR变化呈负相关 (r   =  -  0.410,p  <  0.001) 和CI (r   =  -  0.314,p  <  0.001)。在HA暴露后,具有最低三分位数的基线HR的受试者显示出增加的HR [56 (53,58) vs. 65 (58,73) 次/分,p <0.001],左室射血分数 (LVEF) [61.7 (56.5,68.0) vs. 66.1 (60.7,71.5) %,p   =   0.004]二尖瓣速度 [5.8 ± 1.4比6.5 ± 1.9厘米/s,p = 0.040]。然而,基线HR最高的受试者显示HR、LVEF和二尖瓣速度不变,但E' 速度降低 [9.2 ± 2.0对8.4 ± 1.8厘米/s,p = 0.003]。我们的研究结果表明,海平面的基线HR可以决定心脏对HA暴露的反应; 这些反应的特征是基线HR低的受试者LV功能增强,基线HR高的受试者舒张早期LV心肌速度降低。

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影响因子:1.67
发表时间:2020-01-01
DOI:10.2174/1573403X15666190513105231
作者列表:["Dev M","Sharma M","Rana N"]

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心脏影像技术方向

心脏结构和心脏血流的可视化,用于诊断评估或通过内窥镜、放射性核素成像等技术来指导心脏手术。

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