Role of Interleukin-18 and the Thrombus Precursor Protein in Coronary Artery Disease.
- 作者列表："Scherr C","Albuquerque DC","Pozzan R","Ataide K","Ludmila T","Blanco F","Mangia CM
:Background Coronary failure is the leading cause of death worldwide and identifying patients at higher risk for coronary artery disease (CAD) is a challenge. Objectives To test the biomarkers interleukin 18 (IL-18) and thrombus precursor protein (TpP), involved in atherogenesis, to aid in the early assessment of CAD. Methods This was a cross-sectional cohort of 119 patients, stratified into three groups: Group I - acute coronary syndrome (39); Group II - chronic CAD (40) and Group III - control, without coronary lesion, but who might have risk factors for CAD (40). Statistical analysis was performed using the statistical program SPSS (Statistical Package for the Social Sciences) for Windows ,version 17.0 of 2008. The significance level was set at 0.05 or 5% (p <0.05), with a 95% confidence interval. Chi-square test (χ2), Analysis of variance (ANOVA), and Tukey's test were used. Results The mean age was 60.36 ± 9.64 years; there was a prevalence of females in Group III (65.0% p = 0.002), but without statistical significance for the means of IL-18 and TpP. The means of IL-18 and TpP were increased in Group I when compared to the other groups; IL-18 = 1325.44 ± 1860.13 ng/dL, p = 0.002; TpP = 35.86 ± 28.36 µg / mL, p <0.001). When compared two-by-two, it was observed that Group I had higher mean IL-18 and TpP values than Group II (IL-18 = 353.81 ± 273.65 ng / dL; TpP = 25.66 ± 12, 17 µg / mL) and Group III (IL-18 = 633.25 ± 993.93 ng / dL; TpP = 18.00 ± 8.45 µg / mL). Conclusion There was an increase in these biomarkers in acute CAD, suggesting a relationship with the atherosclerotic plaque instability process, but not with the chronic phase. (Arq Bras Cardiol. 2020; 114(4):692-698).
背景: 冠状动脉衰竭是世界范围内死亡的主要原因，确定冠心病 (CAD) 风险较高的患者是一个挑战。目的检测参与动脉粥样硬化形成的生物标志物白细胞介素18 (IL-18) 和血栓前体蛋白 (TpP)，以帮助早期评估冠心病。方法这是一个由119名患者组成的横断面队列，分为三组: I组-急性冠脉综合征 (39); II组-慢性CAD (40) 和III组-对照，无冠脉病变，但可能有冠心病危险因素 (40)。使用2008年17.0版Windows的统计程序SPSS (社会科学统计软件包) 进行统计分析。显著性水平设定为0.05或5% (p <0.05)，置信区间为95%。采用卡方检验 (χ2 2) 、方差分析 (ANOVA) 和Tukey检验。结果平均年龄为60.36 ± 9.64岁; 组III中女性患病率 (65.0% p = 0.002)，但IL-18和TpP的平均值无统计学意义。与其他组相比，组I中IL-18和TpP的平均值增加; IL-18 = 1325.44 ± 1860.13 ng/dL，p = 0.002; TpP = 35.86 ± 28.36 µ g/mL，p <0.001)。当比较二乘二时，观察到组I的平均IL-18和TpP值高于组II (IL-18 = 353.81 ± 273.65 ng / dL; TpP = 25.66 ± 633.25 μ g / mL) 和组III (IL-18 = 993.93 ± ng / dL;TpP = 18.00 ± 8.45 µ g/mL)。结论急性CAD中这些生物标志物的增加，表明与动脉粥样硬化斑块不稳定过程有关，但与慢性期无关。(Arq Bras Cardiol。2020; 114(4):692-698)。
METHODS::We present the case of a 61-year-old woman with a large tumoral infiltration extending from the pelvis throughout the inferior vena cava inferior to the right atrium, protruding into the right ventricle and right ventricular outflow tract. She had been treated 10 years before for low-grade endometrial stromal sarcoma by hysterectomy and adnexectomy followed by hormone- and radio-therapy. Due to cancer recurrence, she underwent peritonectomy, appendectomy, and resection of terminal ileum.
METHODS:AIMS:Significant platelet activation after long stented coronary segments has been associated with periprocedural microvascular impairment and myonecrosis. In long lesions treated either with an everolimus-eluting bioresorbable vascular scaffold (BVS) or an everolimus-eluting stent (EES), we aimed to investigate (a) procedure-related microvascular impairment, and (b) the relationship of platelet activation with microvascular function and related myonecrosis. METHODS AND RESULTS:Patients (n=66) undergoing elective percutaneous coronary intervention (PCI) in long lesions were randomised 1:1 to either BVS or EES. The primary endpoint was the difference between groups in changes of pressure-derived corrected index of microvascular resistance (cIMR) after PCI. Periprocedural myonecrosis was assessed by high-sensitivity cardiac troponin T (hs-cTnT), platelet reactivity by high-sensitivity adenosine diphosphate (hs-ADP)-induced platelet reactivity with the Multiplate Analyzer. Post-dilatation was more frequent in the BVS group, with consequent longer procedure time. A significant difference was observed between the two groups in the primary endpoint of ΔcIMR (p=0.04). hs-ADP was not different between the groups at different time points. hs-cTnT significantly increased after PCI, without difference between the groups. CONCLUSIONS:In long lesions, BVS implantation is associated with significant acute reduction in IMR as compared with EES, with no significant interaction with platelet reactivity or periprocedural myonecrosis.
METHODS:BACKGROUND:Aortopulmonary window is an uncommon congenital heart disease, with untreated cases not surviving beyond childhood. However, very rarely it can present in adult patients with features of pulmonary hypertension. Clinically these patients cannot be differentiated from other more common conditions with left to right shunt. Transthoracic echocardiography if performed meticulously, can depict the defect in aortopulmonary septum. RESULTS:We report a case of large unrepaired aortopulmonary window in a 23 years old patient, diagnosed on transthoracic echocardiography.