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Extending the Hybrid Surgical Guidance Concept With Freehand Fluorescence Tomography.

用徒手荧光断层扫描扩展混合手术引导概念。

  • 影响因子:0
  • DOI:10.1109/TMI.2019.2924254
  • 作者列表:"van Oosterom MN","Meershoek P","Welling MM","Pinto F","Matthies P","Simon H","Wendler T","Navab N","van de Velde CJH","van der Poel HG","van Leeuwen FWB
  • 发表时间:2020-01-01
Abstract

:Within image-guided surgery, 'hybrid' guidance technologies have been used to integrate the complementary features of radioactive guidance and fluorescence guidance. Here, we explore how the generation of a novel freehand fluorescence (fhFluo) imaging approach complements freehand SPECT (fhSPECT) in a hybrid setup. Near-infrared optical tracking was used to register the position and the orientation of a hybrid opto-nuclear detection probe while recording its readings. Dedicated look-up table models were used for 3D reconstruction. In phantom and excised tissue settings (i.e., flat-surface human skin explants), fhSPECT and fhFluo were investigated for image resolution and in-tissue signal penetration. Finally, the combined potential of these freehand technologies was evaluated on prostate and lymph node specimens of prostate cancer patients receiving prostatectomy and sentinel lymph node dissection (tracers: indocyanine green (ICG) +99m Tc-nanocolloid or ICG-99mTc-nanocolloid). After hardware and software integration, the hybrid setup created 3D nuclear and fluorescence tomography scans. The imaging resolution of fhFluo (1 mm) was superior to that of fhSPECT (6 mm). Fluorescence modalities were confined to a maximum depth of 0.5 cm, while nuclear modalities were usable at all evaluated depths (<2 cm). Both fhSPECT and fhFluo enabled augmented- and virtual-reality navigation toward segmented image hotspots, including relative hotspot quantification with an accuracy of 3.9% and 4.1%. Imaging in surgical specimens confirmed these trends (fhSPECT: in-depth detectability, low resolution, and fhFluo: superior resolution, superficial detectability). Overall, when radioactive and fluorescent tracer signatures are used, fhFluo has complementary value to fhSPECT. Combined the freehand technologies render a unique hybrid imaging and navigation modality.

摘要

: 在图像引导手术中,“混合” 引导技术已被用于整合放射性引导和荧光引导的互补特征。在这里,我们探讨了如何在混合设置中生成新型徒手荧光 (fhFluo) 成像方法来补充徒手SPECT (fhSPECT)。近红外光学跟踪用于记录混合光电探测探头的位置和取向,同时记录其读数。使用专用查找表模型进行三维重建。在体模和切除的组织设置 (即,平坦表面的人皮肤外植体) 中,研究了fhSPECT和fhFluo的图像分辨率和组织内信号穿透。最后,在接受前列腺切除术和前哨淋巴结清扫术的前列腺癌患者的前列腺和淋巴结标本上评估了这些徒手技术的组合潜力 (示踪剂: 吲哚菁绿 (ICG) + 99m Tc-纳米胶体或ICG-99mTc-nanocolloid)。在硬件和软件集成之后,混合装置创建了3D核和荧光断层扫描。fhFluo的成像分辨率 (1毫米) 优于fhSPECT (6毫米)。荧光模式被限制在0.5厘米的最大深度,而核模式在所有评估的深度 (<2厘米) 都可用。fhSPECT和fhFluo都实现了对分割图像热点的增强和虚拟现实导航,包括相对热点量化,准确度为3.9% 和4.1%。手术标本中的成像证实了这些趋势 (fhSPECT: 深度可检测性、低分辨率和fhFluo: 优越的分辨率、表面可检测性)。总的来说,当使用放射性和荧光示踪剂标记时,fhFluo具有与fhSPECT互补的价值。结合徒手技术提供了一种独特的混合成像和导航模式。

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作者列表:["Delattre BMA","Boudabbous S","Hansen C","Neroladaki A","Hachulla AL","Vargas MI"]

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翻译标题与摘要 下载文献
影响因子:2.98
发表时间:2020-01-01
DOI:10.1136/neurintsurg-2019-014962
作者列表:["Guo W","Liu H","Tan Z","Zhang X","Gao J","Zhang L","Guo H","Bai H","Cui W","Liu X","Wu X","Luo J","Qu Y"]

METHODS:BACKGROUND:The main surgical techniques for spontaneous basal ganglia hemorrhage include stereotactic aspiration, endoscopic aspiration, and craniotomy. However, credible evidence is still needed to validate the effect of these techniques. OBJECTIVE:To explore the long-term outcomes of the three surgical techniques in the treatment of spontaneous basal ganglia hemorrhage. METHODS:Five hundred and sixteen patients with spontaneous basal ganglia hemorrhage who received stereotactic aspiration, endoscopic aspiration, or craniotomy were reviewed retrospectively. Six-month mortality and the modified Rankin Scale score were the primary and secondary outcomes, respectively. A multivariate logistic regression model was used to assess the effects of different surgical techniques on patient outcomes. RESULTS:For the entire cohort, the 6-month mortality in the endoscopic aspiration group was significantly lower than that in the stereotactic aspiration group (odds ratio (OR) 4.280, 95% CI 2.186 to 8.380); the 6-month mortality in the endoscopic aspiration group was lower than that in the craniotomy group, but the difference was not significant (OR=1.930, 95% CI 0.835 to 4.465). A further subgroup analysis was stratified by hematoma volume. The mortality in the endoscopic aspiration group was significantly lower than in the stereotactic aspiration group in the medium (≥40-<80 mL) (OR=2.438, 95% CI 1.101 to 5.402) and large hematoma subgroup (≥80 mL) (OR=66.532, 95% CI 6.345 to 697.675). Compared with the endoscopic aspiration group, a trend towards increased mortality was observed in the large hematoma subgroup of the craniotomy group (OR=8.721, 95% CI 0.933 to 81.551). CONCLUSION:Endoscopic aspiration can decrease the 6-month mortality of spontaneous basal ganglia hemorrhage, especially in patients with a hematoma volume ≥40 mL.

影响因子:0.96
发表时间:2020-02-01
DOI:10.1002/jcu.22762
作者列表:["Meng L","Zhao D","Yang Z","Wang B"]

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