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Higher chocolate intake is associated with longer telomere length among adolescents.

青少年中较高的巧克力摄入量与较长的端粒长度相关。

  • 影响因子:2.86
  • DOI:10.1038/s41390-019-0590-6
  • 作者列表:"Chen L","Zhu H","Gutin B","Sesso HD","Dong Y
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Chocolate intake has shown cardiometabolic health benefits. Whether chocolate has any effect on cellular aging remains unknown. We aimed to test the hypothesis that higher chocolate intake is associated with longer leukocyte telomere length (LTL) in adolescents. METHODS:A total of 660 adolescents (aged 14-18 years) were included in the analysis. The chocolate intake was assessed by 7-day, 24-h dietary recalls and split into three groups, which were none, <2 servings/week, and 2 servings/week or more. LTL (T/S ratio) was determined by a modified quantitative polymerase chain reaction-based assay. RESULTS:Among the 660 adolescents, 58% did not take any chocolate, 25% consumed <2 servings/week, and 17% consumed ≥2 servings/week. Compared to non-consumers, adolescents who consumed chocolate of ≥2 servings/week had 0.27 standard deviation (SD) longer LTL (p = 0.014). Higher chocolate consumption was associated with increased apolipoprotein A1 (ApoA1) (p = 0.038) and ApoA1/high-density lipoprotein (HDL) (p = 0.046). Moreover, higher ApoA1/HDL levels were correlated with longer LTL (p = 0.026). CONCLUSION:Adolescents who consume 2 servings/week or more of chocolate candy have longer LTL compared with non-consumers, and ApoA1/HDL pathway may be involved in this relationship.

摘要

背景: 巧克力摄入已显示对心脏代谢健康有益。巧克力是否对细胞老化有任何影响仍然是未知的。我们旨在检验青少年较高的巧克力摄入量与较长的白细胞端粒长度 (LTL) 相关的假设。 方法: 共 660 名青少年 (年龄 14 ~ 18 岁) 纳入分析。通过 7 天、 24 小时的饮食回顾评估巧克力摄入量,并分为三组,

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影响因子:1.65
发表时间:2020-01-13
来源期刊:Nursing research
DOI:10.1097/NNR.0000000000000415
作者列表:["Rodriguez J","Adams-Chapman I","Affuso O","Azuero A","Downs CA","Turner-Henson A","Rice M"]

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影响因子:2.3490
发表时间:2020-01-21
DOI:10.3389/fped.2019.00567
作者列表:["Camilla Sandrini","Claudio Lombardi","Andrew I. U. Shearn","Maria Victoria Ordonez","Massimo Caputo","Francesca Presti","Giovanni Battista Luciani","Lucia Rossetti","Giovanni Biglino","Giovanni Biglino"]

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影响因子:8.02
发表时间:2020-01-19
来源期刊:Genome Medicine
DOI:10.1186/s13073-019-0709-8
作者列表:["Cigdem Sevim Bayrak","Peng Zhang","Martin Tristani-Firouzi","Bruce D. Gelb","Yuval Itan"]

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