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A higher level of total bile acid in early mid-pregnancy is associated with an increased risk of gestational diabetes mellitus: a prospective cohort study in Wuhan, China.

孕早期总胆汁酸水平较高与妊娠期糖尿病风险增加相关: 中国武汉的一项前瞻性队列研究。

  • 影响因子:2.82
  • DOI:10.1007/s40618-020-01196-7
  • 作者列表:"Kong M","Lu Z","Zhong C","Gao Q","Zhou X","Chen R","Xiong G","Hao L","Yang X","Yang N
  • 发表时间:2020-02-22
Abstract

PURPOSE:To assess the longitudinal associations between maternal total bile acid (TBA) levels during early mid-pregnancy and the subsequent risk of gestational diabetes mellitus (GDM). METHODS:In a prospective cohort study, pregnant women who were enrolled prior to gestational week 16 were followed until delivery. TBA levels were tested during weeks 14-18 of gestation. Using logistic regression, we analyzed the associations between quartiles of TBA and GDM based on a 75-g oral glucose tolerance test (OGTT) at 24-28 gestational weeks. RESULTS:The GDM rate was 7.9% (114/1441). The mean TBA level was higher in women with GDM than in those without GDM (2.1 ± 2.0 vs 1.5 ± 1.0 µmol/L, P = 0.000). The highest TBA level quartile (2.1-10.7 µmol/L) had a 1.78-fold (95% CI 1.01, 3.14) increased risk of GDM compared with that of the lowest quartile (0.0-0.8 µmol/L) after adjusting for pre-pregnancy body mass index (BMI), gestational, age at TBA test and other confounders. High TBA levels were involved in the fasting glucose level rather than that at 1 h and 2 h after OGTT in all participants. CONCLUSIONS:Pregnant women with higher serum TBA levels during early mid-pregnancy have a higher risk of developing GDM. TBA may be a new risk factor for GDM.

摘要

目的: 评估妊娠早期母体总胆汁酸 (TBA) 水平与随后发生妊娠期糖尿病 (GDM) 风险之间的纵向相关性。 方法: 在一项前瞻性队列研究中,对妊娠 16 周前入组的孕妇进行随访直至分娩。在妊娠 14-18 周检测 TBA 水平。使用 logistic 回归,我们基于 24-28 孕周 75g 口服葡萄糖耐量试验 (OGTT) 分析了 TBA 四分位数与 GDM 的相关性。 结果: GDM 患病率为 7.9% (114/1441)。GDM 妇女的平均 TBA 水平高于无 GDM 妇女 (2.1 ± 2.0 vs 1.5 ± 1.0 µ mol/L,p = 0.000)。最高 TBA 水平四分位数 (2.1-10.7 µ mol/L) 为 1.78 倍 (95% CI 1.01,3.14) 在调整了孕前体重指数 (BMI) 、妊娠期、 TBA 试验时的年龄和其他混杂因素。所有参与者的空腹血糖水平均涉及高 TBA 水平,而不是 OGTT 后 1 h 和 2 h。 结论: 妊娠早期血清 TBA 水平较高的孕妇发生 GDM 的风险较高。TBA 可能是 GDM 的一个新的危险因素。

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影响因子:3.72
发表时间:2020-01-16
DOI:10.1093/ibd/izz325
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