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Trajectories of physical activity, from young adulthood to older adulthood, and pancreatic cancer risk; a population-based case-control study in Ontario, Canada.

体力活动轨迹,从青年期到大年期,与胰腺癌风险; 加拿大安大略省一项基于人群的病例对照研究。

  • 影响因子:3.29
  • DOI:10.1186/s12885-020-6627-8
  • 作者列表:"Sandhu J","De Rubeis V","Cotterchio M","Smith BT","Griffith LE","Brenner DR","Borgida A","Gallinger S","Cleary S","Anderson LN
  • 发表时间:2020-02-21
Abstract

BACKGROUND:There is inconsistent evidence on the association between physical activity and pancreatic cancer risk and few studies have investigated early life or life-course physical activity. The objective of this study was to evaluate the association between trajectories of physical activity across the life-course and pancreatic cancer risk. METHODS:A population-based case-control study was conducted (2011-2013) using cases (n = 315) from the Ontario Pancreas Cancer Study and controls (n = 1254) from the Ontario Cancer Risk Factor Study. Self-reported recall of moderate and vigorous physical activity was measured at three time points: young adulthood (20s-30s), mid-adulthood (40s-50s) and older-adulthood (1 year prior to questionnaire completion). Physical activity trajectories were identified using latent class analysis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression adjusted for covariates: age, sex, race, alcohol, smoking, vegetable, fruit and meat consumption, and family history of pancreatic cancer. RESULTS:Six life-course physical activity trajectories were identified: inactive at all ages (41.2%), low activity at all ages (31.9%), increasingly active (3.6%), high activity in young adulthood with substantial decrease (13.0%), high activity in young adulthood with slight decrease (5.0%), and persistent high activity (5.3%). Compared to the inactive at all ages trajectory, the associations between each trajectory and pancreatic cancer after confounder adjustment were: low activity at all ages (OR: 1.11; 95% CI: 0.75, 1.66), increasingly active (OR: 1.11; 95% CI: 0.56, 2.21), high activity in young adulthood with substantial decrease in older adulthood (OR: 0.76; 95% CI: 0.47, 1.23), high activity in young adulthood with slight decrease in older adulthood (OR: 0.98; 95% CI: 0.62, 1.53), and persistently high activity (OR: 1.50; 95% CI: 0.86, 2.62). When time periods were evaluated separately, the OR for the association between high moderate activity in the 20s-30s and pancreatic cancer was 0.89 (95% CI: 0.64, 1.25) and some sex differences were observed. CONCLUSION:Distinct life-course physical activity trajectories were identified, but there was no evidence that any of the trajectories were associated with pancreatic cancer. Future studies with larger sample sizes are needed to understand the associations between physical activity trajectories over the life-course and pancreatic cancer risk.

摘要

背景: 关于体力活动与胰腺癌风险之间的关系的证据不一致,很少有研究调查生命早期或生命过程中的体力活动。本研究的目的是评估整个生命过程中身体活动轨迹与胰腺癌风险之间的相关性。 方法: 采用安大略省胰腺癌研究和对照 (n = 2011) 的病例 (n = 2013),进行了以人群为基础的病例对照研究 (315-1254) 来自安大略省癌症危险因素研究。在三个时间点测量中度和剧烈体力活动的自我报告回忆: 青年期 (20s-30 s),中期 (40s-50 s) 和老年-成年 (问卷完成前 1 年)。使用潜在类别分析确定体力活动轨迹。根据多变量 logistic 回归估计比值比 (OR) 和 95% 置信区间 (CI),校正协变量: 年龄、性别、种族、酒精、吸烟、蔬菜、水果和肉类消费, 和胰腺癌家族史。 结果: 确定了六个生命过程体力活动轨迹: 各年龄段不活动 (41.2%),各年龄段活动低 (31.9%),活动日益活跃 (3.6%), 青年期高活动量大幅下降 (13.0%),青年期高活动量轻微下降 (5.0%),持续高活动量 (5.3%)。与所有年龄轨迹的不活动相比,混杂校正后每个轨迹与胰腺癌之间的相关性为: 所有年龄阶段的低活性 (OR: 1.11; 95% CI: 0.75,1.66), 越来越活跃 (OR: 1.11; 95% CI: 0.56,2.21),青年期高活动,大年期大幅下降 (OR: 0.76; 95% CI: 0.47,1.23),青年期高活动,大年期略有下降 (OR: 0.98; 95% CI: 0.62,1.53) 和持续高活性 (OR: 1.50; 95% CI: 0.86,2.62)。当单独评价时间段时,20s-30s 高中度活动与胰腺癌相关性的 OR 为 0.89 (95% CI: 0.64,1.25),观察到一些性别差异。 结论: 确定了不同的生命过程体力活动轨迹,但没有证据表明任何轨迹与胰腺癌相关。未来需要更大样本量的研究来了解生命过程中的体力活动轨迹与胰腺癌风险之间的关联。

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发表时间:2020-01-28
DOI:10.1080/17425247.2020.1723544
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作者列表:["Okada KI","Kawai M","Hirono S","Kojima F","Tanioka K","Terada M","Miyazawa M","Kitahata Y","Iwahashi Y","Ueno M","Hayami S","Murata SI","Shimokawa T","Yamaue H"]

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