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PD-1 gene rs10204525 and rs7421861 polymorphisms are associated with increased risk and clinical features of esophageal cancer in a Chinese Han population.

PD-1 基因 rs10204525 和 rs7421861 多态性与中国汉族人群食管癌风险增加和临床特征相关。

  • 影响因子:5.5150
  • DOI:10.18632/aging.102845
  • 作者列表:"Zang B","Chen C","Zhao JQ
  • 发表时间:2020-02-21
Abstract

:Programmed death-1 (PD-1) polymorphisms have been associated with esophageal cancer risk. Here, the aims of this case-control study were to explore whether three PD-1 polymorphisms (rs10204525, rs7421861, and rs36084323) were related with the risk and clinical features of esophageal cancer in Chinese Han subjects (n = 814 cases and 961 controls). We found that rs10204525 and rs7421861, but not rs36084323, conferred increased susceptibility to esophageal cancer. Subgroup analysis revealed that all three loci increased the risk of esophageal cancer among men, and that rs10204525 and rs7421861 correlated with increased risk among patients ≥ 60 years old. The rs10204525 and rs7421861 polymorphisms were associated with higher TNM stage, and rs10204525 was associated with distant metastasis. The combination of smoking and either the rs10204525 or rs7421861 genotype conferred an increased risk to esophageal cancer, which is indicative of potential gene-environment interactions. The rs10204525 and rs7421861 polymorphisms correlated with increased PD-1 gene and protein levels, and Kaplan-Meier survival curves showed higher PD-1 gene expression was related to poorer overall survival. These data indicate the rs10204525 and rs7421861 polymorphisms of PD-1 gene confer an increased risk of esophageal cancer among Chinese Han individuals.

摘要

: 程序性死亡-1 (PD-1) 多态性与食管癌风险相关。本病例对照研究的目的是探讨三种 PD-1 多态性 (rs10204525 、 rs7421861 和 rs36084323) 与中国汉族人群 (n = 814 例,对照组 961 例) 食管癌发病风险及临床特征有关。我们发现 rs10204525 和 rs7421861,而不是 rs36084323,增加了食管癌的易感性。亚组分析发现,所有 3 个位点均增加了男性食管癌的风险,rs10204525 和 rs7421861 与 ≥ 60 岁患者的风险增加相关。Rs10204525 和 rs7421861 多态性与较高的 TNM 分期相关,rs10204525 与远处转移相关。吸烟和 rs10204525 或 rs7421861 基因型的结合使食管癌的风险增加,这表明潜在的基因-环境相互作用。Rs10204525 和 rs7421861 多态性与 PD-1 基因和蛋白水平增加相关,Kaplan-Meier 生存曲线显示较高的 PD-1 基因表达与较差的总生存期相关。这些数据表明 PD-1 基因 rs10204525 和 rs7421861 多态性增加了中国汉族人群患食管癌的风险。

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影响因子:1.24
发表时间:2020-01-01
DOI:10.3892/etm.2019.8190
作者列表:["Shang L","Pei QS","Xu D","Liu JY","Liu J"]

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翻译标题与摘要 下载文献
影响因子:2.64
发表时间:2020-01-01
DOI:10.1007/s11605-019-04456-x
作者列表:["Campos VJ","Mazzini GS","Juchem JF","Gurski RR"]

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