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Menthol relieves acid reflux inflammation by regulating TRPV1 in esophageal epithelial cells.

薄荷醇通过调节食管上皮细胞 TRPV1 缓解酸反流炎症。

  • 影响因子:2.69
  • DOI:10.1016/j.bbrc.2020.02.050
  • 作者列表:"Zhang Z","Wu X","Zhang L","Mao A","Ma X","He D
  • 发表时间:2020-02-17
Abstract

:Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays an important role in pain and inflammatory responses. Previous studies have shown that the expression of TRPV1 increases in the sensory neurons of the esophagus during the development of gastroesophageal reflux disease and esophagitis, but the response of TRPV1 in esophageal epithelial cells (EECs), which directly confront the refluxed acid, is still unknown. Here, we found that acid reflux triggered esophageal damage, which was accompanied by increased expression of TRPV1 in EECs and TRPV1 channel activity in these cells. Furthermore, menthol inhibited the Ca2+ influx induced by acid stimulation in EECs. After menthol treatment, the expression of TRPV1 in EECs was significantly reduced, and their hyperplasia was significantly reduced; finally, the inflammation pathway elicited in EECs was diminished in mice with acid reflux. These results suggest that menthol improves the clinical symptoms caused by gastroesophageal acid reflux by interfering with TRPV1 in EECs.

摘要

: 瞬时受体电位阳离子通道亚家族 V 成员 1 (TRPV1) 在疼痛和炎症反应中起重要作用。既往研究表明,在胃食管反流病和食管炎的发展过程中,TRPV1 在食管感觉神经元中的表达增加,但 TRPV1 在食管上皮细胞 (EECs) 中的反应, 它直接面对回流酸,仍然是未知的。在这里,我们发现酸反流触发了食管损伤,伴随着 EECs 中 TRPV1 的表达增加和这些细胞中 TRPV1 通道活性的增加。此外,薄荷醇抑制了酸刺激诱导的 EECs 中 Ca2 + 内流。薄荷醇处理后,EECs 中 TRPV1 的表达显著减少,其增生显著减少; 最后,酸反流小鼠 EECs 中引发的炎症通路减少。这些结果提示薄荷醇通过干扰 EECs 中 TRPV1 改善胃食管酸反流引起的临床症状。

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