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Epidemiology of irritable bowel syndrome and its associated factors in Saudi undergraduate students.

沙特大学生肠易激综合征流行病学相关因素。

  • 影响因子:1.34
  • DOI:10.4103/sjg.SJG_459_19
  • 作者列表:"AlButaysh OF","AlQuraini AA","Almukhaitah AA","Alahmdi YM","Alharbi FS
  • 发表时间:2020-02-07
Abstract

Background/Aim:Irritable bowel syndrome (IBS) is common among undergraduate students and is associated with several modifiable risk factors. The present study aimed to explore the epidemiology of IBS in Saudi undergraduate students. Materials and Methods:A cross-sectional study was carried out from February 2018 to June 2018. A total of 767 undergraduate students from all regions of Saudi Arabia completed an online self-administered questionnaire. IBS symptoms were assessed using the Rome IV diagnostic criteria. Results:The mean age was 21.88 years (range 18-29); 56.1% of the study population were females and 50.1% were from the central region of Saudi Arabia. Students of medical colleges represented 30.2% of the sample. The overall prevalence of IBS was 15.8%. Significant independent risk factors for IBS were female sex (OR = 3.738; 95% CI = 2.093, 6.673), being a student in a medical college (OR = 7.216; 95% CI = 4.438, 11.733), living in a rented apartment (OR = 6.752; 95% CI = 2.586, 17.627), living on campus (OR = 6.563; 95% CI = 2.138, 20.145), poor sleep quality (OR = 3.156; 95% CI = 1.850, 5.385), exercise (OR = 0.394; 95% CI = 0.193, 0.803), smoking (OR = 5.256; 95% CI = 2.841, 9.724), family history of IBS (OR = 1.641; 95% CI = 1.012, 2.661), and emotional stress (OR = 2.184; 95% CI = 1.375, 3.469). Conclusion:Overall, 15.8% of participants in this study met the Rome IV criteria for IBS diagnosis. IBS was associated with several lifestyle factors, as well as family history and emotional stress.

摘要

背景/目的: 肠易激综合征 (IBS) 在大学生中很常见,并且与几种可改变的危险因素相关。本研究旨在探讨沙特大学生 IBS 流行病学学。 材料与方法: 2018年2月至 2018年6月进行横断面研究。来自沙特阿拉伯所有地区的共有 767 名本科生完成了在线自填式问卷。使用罗马 IV 诊断标准评估 IBS 症状。 结果: 平均年龄 21.88 岁 (范围 18-29 岁); 56.1% 的研究人群为女性,50.1% 来自沙特阿拉伯中部地区。医学院的学生占样本的 30.2%。IBS 的总患病率为 15.8%。IBS 的独立危险因素为女性 (OR = 3.738; 95% CI = 2.093,6.673) 、在校大学生 (OR = 7.216; 95% CI = 4.438, 11.733) 、居住在租来的公寓 (OR = 6.752; 95% CI = 2.586,17.627) 、居住在校园 (OR = 6.563; 95% CI = 2.138,20.145) 、睡眠质量差 (OR = 3.156; 95% CI = 1.850,5.385) 、运动 (OR = 0.394; 95% CI = 0.193,0.803) 、吸烟 (OR = 5.256; 95% CI = 2.841,9.724) 、IBS 家族史 (OR = 1.641; 95% CI = 1.012,2.661) 和情绪压力 (OR = 2.184; 95% CI = 1.375,3.469)。 结论: 总体而言,本研究中 15.8% 的参与者符合 IBS 诊断的罗马 IV 标准。IBS 与几种生活方式因素,以及家族史和情绪压力有关。

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影响因子:3.72
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METHODS:BACKGROUND:Peripheral blood eosinophilia (PBE) is a biomarker of an aggressive multiyear natural history in adults with inflammatory bowel diseases (IBDs). Additionally, PBE at diagnosis is associated with higher disease activity in pediatric-onset IBD. We sought to determine if PBE can function as a biomarker of long-term disease severity in pediatric-onset IBD patients who are followed into adulthood. METHODS:We analyzed a consented, prospective, natural history IBD registry at an adult tertiary center from 2009 to 2018. Prevalence of PBE was evaluated in both pediatric- and adult-onset IBD patients. Demographics, clinical characteristics, and health care utilization data were compared in patients with and without PBE. RESULTS:Among 2800 adult IBD patients, 23.4% had pediatric-onset disease. PBE was found in 34% of the pediatric-onset patients compared with 26.8% of the adult-onset IBD patients (P < 0.001). In the pediatric-onset IBD cohort, PBE was associated with higher rates of allergies (P < 0.0001), but not of asthma, allergic rhinitis, or primary sclerosing cholangitis. In the adult IBD patients with pediatric-onset disease, PBE was associated with higher rates of C-reactive protein elevation (P < 0.0001), erythrocyte sedimentation rate elevation (P < 0.0001), higher health care utilization, and higher average health care charges per year (P < 0.00001). CONCLUSIONS:Peripheral blood eosinophilia was more prevalent in adult IBD patients with pediatric-onset compared with adult-onset disease. Among all IBD patients with long-term follow-up, PBE defined a subgroup with more severe illness. These data suggest that PBE may be a biomarker for a high-risk subgroup with high cost trajectory and long-term severity in pediatric-onset IBD that persists into adulthood.

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影响因子:3.72
发表时间:2020-01-21
DOI:10.1093/ibd/izz331
作者列表:["Ronchetti S","Gentili M","Ricci E","Migliorati G","Riccardi C"]

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关键词: GILZ IBD 自身免疫 炎症
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