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LncRNA AK045171 protects the heart from cardiac hypertrophy by regulating the SP1/MG53 signalling pathway.

LncRNA AK045171 通过调节 SP1/MG53 信号通路保护心脏免于心肌肥厚。

  • 影响因子:5.5150
  • DOI:10.18632/aging.102668
  • 作者列表:"Xu L","Wang H","Jiang F","Sun H","Zhang D
  • 发表时间:2020-02-21
Abstract

:Hearts often undergo abnormal remodelling and hypertrophic growth in response to pathological stress. Long non-coding RNAs (LncRNAs) can change cardiac function and participate in regulation of cardiac hypertrophy. The present study aims to identify the role of AK045171 in cardiac hypertrophy and the underlying mechanism in hypertrophic cascades. Mice with cardiac hypertrophy were established through transverse aortic constriction (TAC). Cardiac hypertrophy in cardiomyocytes was induced by angiotensin II (angII). The expression of AK045171 and its target gene SP1 was examined in cardiomyocytes transfected with miRNA. The AK045171 expression level was downregulated in mice after TAC surgery. Overexpression of AK045171 attenuated cardiac hypertrophy both in vitro and in vivo. The mechanism study indicated that AK045171 binds with SP1, which promotes transcription activation of MEG3. It is suggested that overexpression of AK045171 might have clinical potential to suppress cardiac hypertrophy and heart failure.

摘要

: 心脏对病理性应激反应常发生异常重塑和肥大生长。长链非编码 rna (Long non-coding RNAs,LncRNAs) 可改变心脏功能,参与心肌肥厚的调控。本研究旨在确定 AK045171 在心肌肥厚中的作用以及肥厚级联反应的潜在机制。通过主动脉缩窄术 (TAC) 建立心肌肥厚小鼠。血管紧张素 ⅱ (angII) 诱导心肌细胞肥大。在转染 miRNA 的心肌细胞中检测 AK045171 及其靶基因 SP1 的表达。TAC 术后小鼠 AK045171 表达水平下调。过表达 AK045171 可减轻体内外心肌肥厚。机制研究表明,AK045171 与 SP1 结合,促进 meg3 的转录激活。提示过表达 AK045171 可能具有抑制心肌肥厚和心力衰竭的临床潜力。

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发表时间:2020-01-12
DOI:10.1186/s12872-019-01311-4
作者列表:["Nattawut Wongpraparut","Sarawut Siwamogsatham","Tomorn Thongsri","Pornchai Ngamjanyaporn","Arintaya Phrommintikul","Kompoj Jirajarus","Tarinee Tangcharoen","Kid Bhumimuang","Pinij Kaewsuwanna","Rungroj Krittayaphong","Rungtiwa Pongakasira","Harvey D. White"]

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影响因子:4.69
发表时间:2020-01-07
DOI:10.1186/s12968-019-0590-z
作者列表:["Yao-Dan Liang","Yuan-Wei Xu","Wei-Hao Li","Ke Wan","Jia-Yu Sun","Jia-Yi Lin","Qing Zhang","Xiao-Yue Zhou","Yu-Cheng Chen"]

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影响因子:4.69
发表时间:2020-01-05
DOI:10.1186/s12968-019-0589-5
作者列表:["Yingxia Yang","Gang Yin","Yong Jiang","Lei Song","Shihua Zhao","Minjie Lu"]

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