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Sinonasal quality-of-life declines in cystic fibrosis patients with pulmonary exacerbations.

伴有肺部恶化的囊性纤维化患者的鼻窦生活质量下降。

  • 影响因子:2.11
  • DOI:10.1002/alr.22485
  • 作者列表:"Safi C","DiMango E","Keating C","Zhou Z","Gudis DA
  • 发表时间:2020-02-01
Abstract

BACKGROUND:In cystic fibrosis (CF), the relationship between chronic rhinosinusitis (CRS) and pulmonary disease is poorly understood. The purpose of this study was to evaluate the relationship between scores on the 22-item Sino-Nasal Outcome Test (SNOT-22) and CF Questionnaire-revised for adolescents and adults over 14 (CFQ-R 14+), and pulmonary function tests in 2 cohorts of CF patients: those at their baseline health and those with a pulmonary exacerbation. METHODS:Patients >18 years old seen in a Cystic Fibrosis Foundation-accredited clinic completed the SNOT-22 and CFQ-R 14+ instruments. Patients presenting for routine care represented the baseline cohort. Patients diagnosed with a pulmonary exacerbation represented the exacerbation cohort. Average SNOT-22 and CFQ-R 14+ scores for both groups were compared using a 2-sample t test, and correlation coefficient was calculated. RESULTS:One hundred three patients were enrolled over 3 months (30 exacerbations and 73 baseline). Patients' mean age was 32 years (56% female and 44% male). Average SNOT-22 and CFQ-R 14+ scores were significantly worse for exacerbation patients (p = 0.001 and p = 0.0003, respectively). Percent predicted forced expiratory volume in 1 second and forced vital capacity were both higher for baseline patients (p = 0.002 and p = 0.001, respectively). Average SNOT-22 score for all patients was worse than the average score for non-CF, non-CRS patients. CONCLUSION:CF patients with pulmonary exacerbations have worse SNOT-22 and CFQ-R 14+ scores than CF patients at their baseline health. This finding suggests a temporal relationship between sinonasal and pulmonary quality of life, and that worsening of both is associated with reduced pulmonary function.

摘要

背景: 在囊性纤维化 (CF) 中,慢性鼻-鼻窦炎 (CRS) 与肺部疾病之间的关系知之甚少。本研究的目的是评估 22 项 Sino-nose 结果测试 (SNOT-22) 得分之间的关系和 CF 问卷-14 岁以上青少年和成人修订 (CFQ-R 14 +),以及 2 个 CF 患者队列的肺功能测试: 那些处于基线健康状态和肺部恶化的患者。 方法: 在囊性纤维化基金会认可的诊所就诊的> 18 岁患者完成了 SNOT-22 和 CFQ-R 14 + 器械。常规护理的患者代表基线队列。诊断为肺加重的患者代表了加重队列。采用 2 样本 t检验比较两组平均 SNOT-22 和 CFQ-R 14 + 评分,并计算相关系数。 结果: 133 例患者入选 3 个月 (30 例急性加重和 73 例基线)。患者的平均年龄为 32 岁 (56% 为女性,44% 为男性)。恶化患者的平均 SNOT-22 和 CFQ-R 14 + 评分显著更差 (分别为 p = 0.001 和 p = 0.0003)。基线患者 1 秒用力呼气容积和用力肺活量的预测百分比均较高 (分别为 p = 0.002 和 p = 0.001)。所有患者的平均 SNOT-22 评分均差于非 CF 、非 CRS 患者的平均评分。 结论: CF 合并肺急性加重的患者在基线健康时的 SNOT-22 和 CFQ-R 14 + 评分均比 CF 患者差。这一发现表明鼻腔鼻窦和肺部生活质量之间的时间关系,两者的恶化与肺功能降低有关。

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翻译标题与摘要 下载文献
影响因子:4.40
发表时间:2020-01-01
DOI:10.1007/s00262-019-02431-8
作者列表:["Shibaki, Ryota","Murakami, Shuji","Matsumoto, Yuji","Yoshida, Tatsuya","Goto, Yasushi","Kanda, Shintaro","Horinouchi, Hidehito","Fujiwara, Yutaka","Yamamoto, Nobuyuki","Kusumoto, Masahiko","Yamamoto, Noboru","Ohe, Yuichiro"]

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翻译标题与摘要 下载文献
影响因子:4.04
发表时间:2020-01-25
来源期刊:New biotechnology
DOI:10.1016/j.nbt.2019.08.006
作者列表:["Sousa SA","Soares-Castro P","Seixas AMM","Feliciano JR","Balugas B","Barreto C","Pereira L","Santos PM","Leitão JH"]

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