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Intraocular pressure fluctuation and neurodegeneration in the diabetic rat retina.

糖尿病大鼠视网膜眼压波动与神经退行性病变。

  • 影响因子:6.12
  • DOI:10.1111/bph.15033
  • 作者列表:"Jung KI","Woo JE","Park CK
  • 发表时间:2020-02-22
Abstract

BACKGROUND AND PURPOSE:Early retinal neurodegeneration occurs as one of the complications of diabetes even before clinically detectable diabetic vascular retinopathy. The pathogenesis of retinal diabetic neuropathy is still not well understood. We investigated the serial changes or fluctuations in intraocular pressure (IOP) and examined their roles in the pathogenesis of neuronal degeneration in diabetic retina. EXPERIMENTAL APPROACH:The streptozotocin-induced diabetic rats were given brinzolamide ophthalmic suspension, latanoprost ophthalmic solution or saline for 8 weeks. The combined treatment group was treated with both brinzolamide and latanoprost. KEY RESULTS:The fluctuation of IOP was higher in the diabetes group than in the normal control or the combined treatment group. The diabetes-induced apoptosis of retinal ganglion cells (RGCs) was decreased by combined treatment. The increased glial fibrillary acidic protein or Iba-1 expression in the retina or optic nerve head induced by diabetes was attenuated only by the combined treatment. Intercellular adhesion molecule 1 was increased in diabetic rats but not in the combined treatment group. CONCLUSIONS AND IMPLICATIONS:Elevated IOP fluctuations seemed to be associated with the gliosis, neuroinflammation, and neurodegeneration induced by diabetes. The loss of RGCs might be relieved by IOP-lowering medication. The improvement of unstable perfusion pressure could play a role in neuroprotection in the diabetic retina.

摘要

背景和目的: 早期视网膜神经退行性病变是糖尿病的并发症之一,甚至在临床发现糖尿病血管视网膜病变之前就已发生。视网膜糖尿病神经病变的发病机制尚不十分清楚。我们研究了眼压 (IOP) 的系列变化或波动,并检测了它们在糖尿病视网膜神经元变性发病机制中的作用。 实验方法: 链脲佐菌素诱导的糖尿病大鼠给予布林佐胺眼用混悬液、拉坦前列素眼用溶液或生理盐水灌胃 8 周。联合治疗组采用布林佐胺和拉坦前列素治疗。 主要结果: 糖尿病组眼压波动高于正常对照组或联合治疗组。联合治疗可减少糖尿病诱导的视网膜神经节细胞 (RGCs) 凋亡。糖尿病引起的视网膜或视神经头部胶质纤维酸性蛋白或 Iba-1 表达增加仅在联合治疗下减弱。糖尿病大鼠细胞间粘附分子 1 升高,而联合治疗组无升高。 结论和意义: 眼压波动升高似乎与糖尿病诱导的胶质细胞增生、神经炎症和神经变性有关。RGCs 的丢失可能通过降眼压药物来缓解。不稳定灌注压的改善对糖尿病视网膜具有神经保护作用。

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影响因子:19.14
发表时间:2020-01-01
来源期刊:Nature Medicine
DOI:10.1038/s41591-019-0724-8
作者列表:["Artzi, Nitzan Shalom","Shilo, Smadar","Hadar, Eran","Rossman, Hagai","Barbash-Hazan, Shiri","Ben-Haroush, Avi","Balicer, Ran D.","Feldman, Becca","Wiznitzer, Arnon","Segal, Eran"]

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关键词: 暂无
翻译标题与摘要 下载文献
影响因子:4.34
发表时间:2020-01-27
DOI:10.1128/AAC.01777-19
作者列表:["Lowes DJ","Hevener KE","Peters BM"]

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