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Association between periodontitis and systemic medications intake: A case-control study.

牙周炎与全身药物摄入之间的相关性: 一项病例对照研究。

  • 影响因子:2.94
  • DOI:10.1002/JPER.19-0593
  • 作者列表:"Wang IC","Askar H","Ghassib I","Wang CW","Wang HL
  • 发表时间:2020-02-20
Abstract

BACKGROUND:To investigate the frequency of systemic drugs taken by elderly patients with or without periodontitis and the possible association between medication consumption and the severity of periodontitis. METHODS:A total of 1221 patients, including 608 with generalized moderate to severe periodontitis (periodontitis group) and 613 age- and gender-matched individuals with healthy periodontium (healthy group) were selected. Systemic conditions, medications and periodontal status were recorded. Medication intake frequency (%) was compared using unconditional logistic regression. RESULTS:The top three most common medications were angiotensin-converting enzyme (ACE) inhibitors (17.9%), antidepressants (17.8%), and lipid-lowering medications (16.5%). Both ACE inhibitors and antidepressants showed statistically higher intake frequency in the periodontitis group relative to healthy controls (21.5 vs. 14.4%; odds ratio (OR) = 1.64), (21.1 vs. 14.5%, OR = 1.57) (P < 0.01). Additionally, intake of oral hypoglycemic agents, calcium channel blockers, insulin and diuretics were significantly higher in the periodontitis group with OR = 2.49, 2.32, 2.08 and 1.79, respectively (P < 0.05). Several medications demonstrated a disease severity-dependent association comparing generalized severe periodontitis with moderate periodontitis and healthy group: oral hypoglycemic agents (17.4 vs. 16.8 vs. 8.0%), calcium channel blockers (14.8 vs. 14.4 vs. 8.0%) and anticonvulsants (13.4 vs. 7.7 vs. 6.4%) with OR of 2.43, 1.99, and 2.28 (severe periodontitis vs. healthy group), respectively. CONCLUSION:There was a significantly higher frequency of medication intake related to cardiovascular disease and diabetes in patients with periodontitis. A disease severity-dependence with medication intake frequency was also noted. This study provides indirect evidence for the possible relationship between systemic diseases and periodontitis. This article is protected by copyright. All rights reserved.

摘要

背景: 调查伴或不伴牙周炎的老年患者全身用药的频率,以及用药与牙周炎严重程度之间的可能关联。 方法: 选择 1221 例患者,包括 608 例泛发性中重度牙周炎患者 (牙周炎组) 和 613 例年龄、性别匹配的健康牙周组织患者 (健康组)。记录全身情况、药物和牙周状况。使用非条件 logistic 回归比较药物摄入频率 (%)。 结果: 前三位最常见的药物是血管紧张素转换酶 (ACE) 抑制剂 (17.9%),抗抑郁药 (17.8%) 和降脂药物 (16.5%)。与健康对照组相比,牙周炎组 ACE 抑制剂和抗抑郁药的摄入频率在统计学上均较高 (21.5 vs. 14.4%; 比值比 (OR) = 1.64),(21.1 vs. 14.5%,OR = 1.57) (P

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影响因子:3.03
发表时间:2020-01-02
来源期刊:Pituitary
DOI:10.1007/s11102-019-01023-0
作者列表:["Galm, Brandon P.","Buckless, Colleen","Swearingen, Brooke","Torriani, Martin","Klibanski, Anne","Bredella, Miriam A.","Tritos, Nicholas A."]

METHODS:Purpose Given the paucity of reliable predictors of tumor recurrence, progression, or response to somatostatin receptor ligand (SRL) therapy in acromegaly, we attempted to determine whether preoperative MR image texture was predictive of these clinical outcomes. We also determined whether image texture could differentiate somatotroph adenomas from non-functioning pituitary adenomas (NFPAs). Methods We performed a retrospective study of patients with acromegaly due to a macroadenoma who underwent transsphenoidal surgery at our institution between 2007 and 2015. Clinical data were extracted from electronic medical records. MRI texture analysis was performed on preoperative non-enhanced T1-weighted images using ImageJ (NIH). Logistic and Cox models were used to determine if image texture parameters predicted outcomes. Results Eighty-nine patients had texture parameters measured, which were compared to that of NFPAs, while 64 of these patients had follow-up and were included in the remainder of analyses. Minimum pixel intensity, skewness, and kurtosis were significantly different in somatotroph adenomas versus NFPAs (area under the receiver operating characteristic curve, 0.7771, for kurtosis). Furthermore, those with a maximum pixel intensity above the median had an increased odds of IGF-I normalization on SRL therapy (OR 5.96, 95% CI 1.33–26.66), which persisted after adjusting for several potential predictors of response. Image texture did not predict tumor recurrence or progression. Conclusion Our data suggest that MRI texture analysis can distinguish NFPAs from somatotroph macroadenomas with good diagnostic accuracy and can predict normalization of IGF-I with SRL therapy.

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影响因子:4.48
发表时间:2020-01-01
DOI:10.1016/j.trsl.2019.07.013
作者列表:["Xiong Y","Tang Y","Fan F","Zeng Y","Li C","Zhou G","Hu Z","Zhang L","Liu Z"]

METHODS::Growth hormone-secreting pituitary adenoma (GHPA), a benign endocrine tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.

关键词: 暂无
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影响因子:5.19
发表时间:2020-01-01
DOI:10.1210/clinem/dgz033
作者列表:["Arlien-Søborg MC","Grøndahl C","Bæk A","Dal J","Madsen M","Høgild ML","Pedersen SB","Bjerre M","Jørgensen JOL"]

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