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Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection.

冠状病毒病的胸部 CT 表现-19 (新型冠状病毒肺炎): 与感染持续时间的关系。

  • 影响因子:5.83
  • DOI:10.1148/radiol.2020200463
  • 作者列表:"Bernheim A","Mei X","Huang M","Yang Y","Fayad ZA","Zhang N","Diao K","Lin B","Zhu X","Li K","Li S","Shan H","Jacobi A","Chung M
  • 发表时间:2020-02-20
Abstract

:In this retrospective study, chest CTs of 121 symptomatic patients infected with coronavirus disease-19 (COVID-19) from four centers in China from January 18, 2020 to February 2, 2020 were reviewed for common CT findings in relationship to the time between symptom onset and the initial CT scan (i.e. early, 0-2 days (36 patients), intermediate 3-5 days (33 patients), late 6-12 days (25 patients)). The hallmarks of COVID-19 infection on imaging were bilateral and peripheral ground-glass and consolidative pulmonary opacities. Notably, 20/36 (56%) of early patients had a normal CT. With a longer time after the onset of symptoms, CT findings were more frequent, including consolidation, bilateral and peripheral disease, greater total lung involvement, linear opacities, "crazy-paving" pattern and the "reverse halo" sign. Bilateral lung involvement was observed in 10/36 early patients (28%), 25/33 intermediate patients (76%), and 22/25 late patients (88%).

摘要

: 在这项回顾性研究中,121 例有症状的冠状病毒病感染患者的胸部 CTs-19 (新型冠状病毒肺炎) 回顾了 2020年1月18日至 2020年2月2日中国 4 个中心的常见 CT 表现与症状发作至初次 ct扫描时间的关系 (i。 e.早期,0-2 天 (36 例),中间 3-5 天 (33 例),晚期 6-12 天 (25 例))。影像学上新型冠状病毒肺炎感染的标志是双侧及周边磨玻璃和肺部混浊。值得注意的是,20/36 (56%) 的早期患者 CT 正常。随着症状出现时间的延长,CT 表现更常见,包括实变、双侧及周围性疾病、全肺受累、线状影、 “疯狂铺路” 图案和 “反向光环” 标志。在 10/36 例早期患者 (28%) 、 25/33 例中间患者 (76%) 和 22/25 例晚期患者 (88%) 中观察到双侧肺受累。

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DOI:10.1111/bph.14861
作者列表:["De Cunto G","Brancaleone V","Riemma MA","Cerqua I","Vellecco V","Spaziano G","Cavarra E","Bartalesi B","D'Agostino B","Lungarella G","Cirino G","Lucattelli M","Roviezzo F"]

METHODS:BACKGROUND AND PURPOSE:A critical role for sphingosine kinase/sphingosine-1-phosphate (S1P) pathway in the control of airway function has been demonstrated in respiratory diseases. Here, we address S1P contribution in a mouse model of mild chronic obstructive pulmonary disease (COPD). EXPERIMENTAL APPROACH:C57BL/6J mice have been exposed to room air or cigarette smoke up to 11 months and killed at different time points. Functional and molecular studies have been performed. KEY RESULTS:Cigarette smoke caused emphysematous changes throughout the lung parenchyma coupled to a progressive collagen deposition in both peribronchiolar and peribronchial areas. The high and low airways showed an increased reactivity to cholinergic stimulation and α-smooth muscle actin overexpression. Similarly, an increase in airway reactivity and lung resistances following S1P challenge occurred in smoking mice. A high expression of S1P, Sph-K2 , and S1P receptors (S1P2 and S1P3 ) has been detected in the lung of smoking mice. Sphingosine kinases inhibition reversed the increased cholinergic response in airways of smoking mice. CONCLUSIONS AND IMPLICATIONS:S1P signalling up-regulation follows the disease progression in smoking mice and is involved in the development of airway hyperresponsiveness. Our study defines a therapeutic potential for S1P inhibitors in management of airways hyperresponsiveness associated to emphysema in smokers with both asthma and COPD.

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影响因子:3.94
发表时间:2020-01-15
DOI:10.1016/j.taap.2019.114847
作者列表:["Bernstein DM","Toth B","Rogers RA","Kling DE","Kunzendorf P","Phillips JI","Ernst H"]

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影响因子:4.04
发表时间:2020-01-10
DOI:10.1042/BST20191010
作者列表:["Zaragosi LE","Deprez M","Barbry P"]

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