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Statins decrease the risk of acute pancreatitis after endoscopic ultrasound fine-needle aspiration of pancreatic cysts.

他汀类药物可降低内镜超声细针穿刺胰腺囊肿后急性胰腺炎的风险。

  • 影响因子:1.47
  • DOI:10.1016/j.hbpd.2019.10.001
  • 作者列表:"Facciorusso A","Buccino VR","Prete VD","Antonino M","Contaldo A","Muscatiello N
  • 发表时间:2020-02-01
Abstract

BACKGROUND:Basic and clinical studies suggest that statins may prevent and even ameliorate acute pancreatitis. The present study was to evaluate whether statin decreases the risk of acute pancreatitis in patients undergoing endoscopic ultrasound-guided fine-needle aspiration of pancreatic cysts. METHODS:Out of 456 patients with pancreatic cysts referred to our center between 2006 and 2018, 365 were finally included in analyses: 86 were treated with statins and 279 were not at the time of endoscopic ultrasound fine-needle aspiration. We compared the acute pancreatitis incidence between the two groups, and we also compared other complications such as bleeding and infections. RESULTS:Median age was 64 years [interquartile range (IQR) 62-69] and median cyst size was 24 mm (IQR, 21-29). The most frequent histology was intraductal papillary mucinous neoplasm (45.3% and 42.3% in the two groups, respectively; P = 0.98). All 13 patients experiencing post-endoscopic ultrasound acute pancreatitis were from the control group (4.7%), of which 3 were classified as severe pancreatitis. None of statin users developed post-procedural acute pancreatitis (odds ratio: 0.15; 95% confidence interval: 0.03-0.98; P = 0.03). No difference was registered with regard to severe pancreatitis and other complications. CONCLUSIONS:Statins exert a beneficial role in preventing acute pancreatitis in patients with pancreatic cysts undergoing endoscopic ultrasound-guided fine-needle aspiration. If confirmed in prospective trials, our findings may pave the way to an extensive use of statins as prophylactic agents in pancreatic interventional endoscopy.

摘要

背景: 基础和临床研究表明,他汀类药物可以预防甚至改善急性胰腺炎。本研究旨在评估他汀类药物是否能降低接受内镜超声引导下细针穿刺胰腺囊肿患者发生急性胰腺炎的风险。 方法: 在 456 和 2006年转诊到我们中心的 2018 例胰腺囊肿患者中,365 例最终被纳入分析: 86 例接受他汀类药物治疗,279 例在超声内镜细针穿刺时未接受治疗。比较两组患者的急性胰腺炎发生率,同时比较出血、感染等并发症。 结果: 中位年龄 64 岁 [四分位距 (IQR) 62-69],中位囊肿大小为 24mm (IQR,21-29)。最常见的组织学是导管内乳头状黏液性肿瘤 (两组分别为 45.3% 和 42.3%; p = 0.98)。13 例超声内镜后急性胰腺炎患者均来自对照组 (4.7%),其中 3 例为重症胰腺炎。他汀类药物使用者均未发生术后急性胰腺炎 (比值比: 0.15; 95% 置信区间: 0.03-0.98; p = 0.03)。在重症胰腺炎和其他并发症方面没有登记差异。 结论: 他汀类药物对行超声内镜引导下细针穿刺的胰腺囊肿患者预防急性胰腺炎具有有益作用。如果在前瞻性试验中得到证实,我们的研究结果可能为广泛使用他汀类药物作为胰腺介入内镜检查的预防药物铺平道路。

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