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Chemoradiotherapy and radiotherapy alone in patients with esophageal cancer aged 80 years or older based on the Comprehensive Registry of Esophageal Cancer in Japan.

基于日本食管癌综合登记处的 80 岁及以上食管癌患者的放化疗和单纯放疗。

  • 影响因子:1.78
  • DOI:10.1007/s10388-020-00725-w
  • 作者列表:"Jingu K","Numasaki H","Toh Y","Nemoto K","Uno T","Doki Y","Matsubara H
  • 发表时间:2020-02-22
Abstract

BACKGROUND:There has been no definitive evidence of chemoradiotherapy being superior to radiotherapy alone in patients aged 80 years or older. The purpose of the present study was to evaluate the results of radiotherapy and chemoradiotherapy in patients aged 80 years or older with esophageal cancer in the Japanese Nationwide Cancer Database. METHODS:A total of 358 patients aged 80 years or older who were treated with radiotherapy alone or with chemoradiotherapy for esophageal cancer between 2009 and 2011 were enrolled. RESULTS:The 5-year overall survival (OS) rates in patients with cStages 0-I, II, III and IV were 40.9%, 24.7%, 12.2% and 4.9%, respectively. The 5-year cause-specific survival (CSS) rates in patients aged 80 years or older with cStages 0-I, cStage II, cStage III and cStage IV were 73.5%, 41.4%, 25.3% and 7.4%, respectively. In patients treated with radiotherapy alone, the 5-year OS rates for patients with cStages 0-I, II, III and IV were 36.5%, 12.0%, 5.4% and 0%, respectively. In patients treated with chemoradiotherapy, the 5-year OS rates for patients with cStages 0-I, II, III and IV were 45.0%, 36.1%, 16.4% and 7.1%, respectively. In multivariate analysis, chemoradiotherapy, early stage and squamous cell carcinoma were significantly favorable prognostic factors for OS in patients aged 80 years or older (p < 0.001, p < 0.001 and p = 0.0323, respectively). We were unable to evaluate toxicities, because of lack of information in the registry. CONCLUSION:Concurrent chemotherapy with radiotherapy for esophageal cancer in patients aged 80 years or older is a significantly favorable prognostic factor for OS. However, chemoradiotherapy should be carefully selected in elderly patients.

摘要

背景: 在 80 岁或以上的患者中,没有确切的证据表明放化疗优于单纯放疗。本研究的目的是评估日本全国癌症数据库中 80 岁或以上食管癌患者的放疗和放化疗结果。 方法: 358 例年龄 ≥ 80 岁的食管癌患者,分别于 2009年和 2011 接受单纯放疗或放化疗治疗。 结果: c0-i 期、 II 期、 III 期和 IV 期患者的 5 年总生存率分别为 40.9% 、 24.7% 、 12.2% 和 4.9%。年龄 ≥ 80 岁的 c 分期 0-I 期、 c 分期 ⅱ 期、 c 分期 ⅲ 期和 c 分期 ⅳ 期患者的 5 年病因特异性生存率 (CSS) 分别为 73.5% 、 41.4% 、 25.3% 和 7.4%,分别。在单纯放疗的患者中,c 分期为 0-I 、 II 、 III 和 IV 的患者 5 年 OS 率分别为 36.5% 、 12.0% 、 5.4% 和 0%。在接受放化疗的患者中,c0-i 期、 II 期、 III 期和 IV 期患者的 5 年 OS 率分别为 45.0% 、 36.1% 、 16.4% 和 7.1%。多因素分析中,放化疗、早期和鳞状细胞癌是 80 岁以上患者 OS 的有利预后因素 (p <0.001,分别为 p <0.001 和 p = 0.0323)。由于注册表中缺乏信息,我们无法评估毒性。 结论: 80 岁以上食管癌患者同步放化疗是 OS 的预后因素。但老年患者应慎重选择放化疗。

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影响因子:1.24
发表时间:2020-01-01
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作者列表:["Shang L","Pei QS","Xu D","Liu JY","Liu J"]

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影响因子:2.64
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