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Impact of Anemia on the Risk of Bleeding Following Percutaneous Coronary Interventions in Patients ≥75 Years of Age.

贫血对 ≥ 75 岁患者经皮冠状动脉介入术后出血风险的影响。

  • 影响因子:2.86
  • DOI:10.1016/j.amjcard.2020.01.010
  • 作者列表:"Martí D","Carballeira D","Morales MJ","Concepción R","Del Castillo H","Marschall A","Delgado-Calva FA","Dejuán-Bitriá C","Pérez-Guzmán J","López-Soberón E","Palazuelos J","Álvarez-Antón S
  • 发表时间:2020-02-19
Abstract

:Bleeding risk stratification is an unresolved issue in older adults. Anemia may reflect subclinical blood losses that can be exacerbated after percutaneous coronary intervention . We sought to prospectively determine the contribution of anemia to the risk of bleeding in 448 consecutive patients aged 75 or more years, treated by percutaneous coronary interventions without concomitant indication for oral anticoagulation. We evaluated the effect of WHO-defined anemia on the incidence of 1-year nonaccess site-related major bleeding. The prevalence of anemia was 39%, and 13.1% of anemic and 5.2% of nonanemic patients suffered a bleeding event (hazard ratio 2.75, 95% confidence interval 1.37 to 5.54, p = 0.004). Neither PRECISE-DAPT nor CRUSADE scores were superior to hemoglobin for the prediction of bleeding. In conclusion, anemia is a powerful predictor of bleeding with potential utility for simplifying tailoring therapies.

摘要

: 出血风险分层是老年人尚未解决的问题。贫血可能反映了经皮冠状动脉介入治疗后可加重的亚临床失血。我们试图前瞻性地确定贫血对 448 例连续 75 岁或以上接受经皮冠状动脉介入治疗且无口服抗凝治疗伴随指征的患者出血风险的影响。我们评价了 WHO 定义的贫血对 1 年非通路部位相关性大出血发生率的影响。贫血患病率为 39%,13.1% 的贫血患者和 5.2% 的非贫血患者发生出血事件 (风险比 2.75,95% 可信区间 1.37 ~ 5.54,p = 0.004)。无论是精确 DAPT 还是 CRUSADE 评分对出血的预测均优于血红蛋白。总之,贫血是出血的有力预测因子,具有简化剪裁疗法的潜在效用。

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影响因子:4.65
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DOI:10.1161/ATVBAHA.119.313602
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