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Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children.

墨西哥儿童代谢健康肥胖与代谢不健康肥胖不同定义的比较。

  • 影响因子:1.22
  • DOI:10.1515/jpem-2019-0077
  • 作者列表:"Evia-Viscarra ML","Guardado-Mendoza R
  • 发表时间:2020-02-25
Abstract

:Background There is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children. Objectives To estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and metabolically unhealthy obesity (MUO), and to evaluate the association between MUO and cardiovascular disease (CVD) risk, anthropometrics and family background using different definitions in children. Methods This was a cross-sectional study. Participants included 224 obese children between the years 2007 and 2017. MHO was defined by three different criteria: (i) absence of metabolic syndrome (MHO-MS), (ii) no insulin resistance (IR) by homeostatic model assessment (HOMA) <3.16 cut-off (MHO-IR3.16) and (iii) absence of IR at <95th percentile for Mexican children (MHO-95th). Results The prevalence of MHO-MS, MHO-IR3.16 and MHO-IR95th was 12.9%, 56.3% and 41.5%, respectively. The prevalence of simultaneous MHO-MS plus MHO-IR95th was 5.36%. Children with MHO-MS vs. MUO-MS showed lower height, weight and body mass index (BMI) percentiles; MHO-IR3.16 vs. MUO-IR3.16 showed lower age, acanthosis, Tanner, waist circumference (WC), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glucose; and MHO-IR95th vs. MUO-IR95th showed lower acanthosis, WC, DBP, glucose and high high-density lipoprotein cholesterol (HDL-C). MUO-MS was associated with WC > 90th, type 2 diabetes mellitus (T2DM) in first-degree relatives and obesity in siblings. MUO-IR3.16 was associated with pubertal stages, WC > 90th, WHtR > 0.55 and fasting hyperglycemia. MUO-IR95th was associated with WHtR > 0.55 and HDL < 10th. MHO-MS and MHO-IR3.16 or MHO-IR95th did not have agreement. Conclusions The prevalence of MHO varied depending on the definition, although the real MHO with no MS or IR is very low. Low DBP and high HDL-C in MHO were present in any definition. Association of MUO with anthropometric, biochemical and family background differs across definitions.

摘要

背景: 代谢健康肥胖 (MHO) 的定义和儿童诊断标准尚未达成共识。目的评估 MHO 的患病率,比较 MHO 与代谢不良肥胖 (MUO) 的临床和生化特征,评价 MHO 与心血管疾病 (CVD) 风险的相关性。人体测量学和家庭背景在儿童中使用不同的定义。方法本研究为横断面研究。参与者包括 224 至 2007年间的 2017 名肥胖儿童。MHO 由三个不同的标准定义 :( i) 无代谢综合征 (MHO-MS),(ii) 无胰岛素抵抗 (IR) 通过稳态模型评估 (HOMA) <3.16 临界值 (MHO-IR3.16) 和 (iii) 墨西哥儿童在 <95 百分位数时没有 IR (MHO-95th)。结果 MHO-MS 、 MHO-IR3.16 和 MHO-IR95th 的患病率分别为 12.9% 、 56.3% 和 41.5%。MHO-MS 合并 MHO-IR95th 的患病率为 5.36%。儿童 MHO-MS vs. MUO-MS 显示身高、体重和体重指数 (BMI) 百分位数较低; MHO-IR3.16 vs. MUO-IR3.16 显示年龄较低,棘皮病,Tanner,腰围 (WC),腰围身高比 (WHtR),收缩压 (SBP),舒张压 (DBP) 和葡萄糖;MHO-IR95th vs. MUO-IR95th 棘皮病、 WC 、 DBP 、葡萄糖、高密度脂蛋白胆固醇 (HDL-C) 降低。MUO-MS 与 wc> 90th 、一级亲属 2 型糖尿病 (T2DM) 和兄弟姐妹肥胖相关。MUO-IR3.16 与青春期、 wc> 90th 、 whtr> 0.55 和空腹高血糖有关。MUO-IR95th 与 whtr> 0.55 和 hdl <10 相关。MHO-MS 和 MHO-IR3.16 或 MHO-IR95th 没有协议。结论 MHO 的患病率因定义而异,尽管无 MS 或 IR 的真正 MHO 很低。MHO 中的低 DBP 和高 HDL-C 存在于任何定义中。MUO 与人体测量、生化和家庭背景的关联因定义而异。

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发表时间:2020-01-24
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发表时间:2020-01-01
DOI:10.1038/s41366-019-0368-2
作者列表:["Wulan, Siti N.","Schrauwen-Hinderling, Vera B.","Westerterp, Klaas R.","Plasqui, Guy"]

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