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Is personality associated with dementia risk? A meta-analytic investigation.

人格与痴呆风险相关吗?一项荟萃分析调查。

  • 影响因子:0
  • DOI:10.1016/j.arr.2021.101269
  • 作者列表:"Aschwanden D","Strickhouser JE","Luchetti M","Stephan Y","Sutin AR","Terracciano A
  • 发表时间:2021-05-01
Abstract

:This study provides a quantitative synthesis of the prospective associations between personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness) and the risk of incident Alzheimer's disease and related dementias. We conducted five separate meta-analyses with 8-12 samples (N = 30,036 to 33,054) that were identified through a systematic literature search following the MOOSE guidelines. Higher neuroticism (HR = 1.24, 95% CI [1.17, 1.31]) and lower conscientiousness (HR = 0.77, 95% CI [0.73, 0.81]) were associated with increased dementia risk, even after accounting for covariates such as depressive symptoms. Lower extraversion (HR = 0.92, 95% CI [0.86, 0.97]), openness (HR = 0.91, 95% CI [0.86, 0.96]), and agreeableness (HR = 0.90, 95% CI [0.83, 0.98]) were also associated with increased risk, but these associations were less robust and not significant in fully adjusted models. No evidence of publication bias was found. The strength of associations was unrelated to publication year (i.e., no evidence of winner's curse). Meta-regressions indicated consistent effects for neuroticism, openness, and conscientiousness across methods to assess dementia, dementia type, follow-up length, sample age, minority, country, and personality measures. The association of extraversion and agreeableness varied by country. Our findings indicate robust associations of neuroticism and conscientiousness with dementia risk.

摘要

: 本研究定量综合了人格特征 (神经质、外向性、开放性、宜人性、责任心) 与阿尔茨海默病和相关痴呆风险之间的前瞻性关联。我们对8-12个样本 (N = 30,036 ~ 33,054) 进行了5项独立的荟萃分析,这些样本是按照MOOSE指南通过系统文献检索确定的。较高的神经质 (HR = 1.24,95% CI [1.17,1.31]) 和较低的责任心 (HR = 0.77,95% CI [0.73,0.81]) 与痴呆风险增加相关,即使在考虑抑郁症状等协变量之后。较低的外向性 (HR = 0.92,95% CI [0.86,0.97]),开放性 (HR = 0.91,95% CI [0.86,0.96]) 和宜人性 (HR = 0.90,95% CI [0.83,0.98]) 也与风险增加相关,但是这些关联在完全调整的模型中不太稳健并且不显著。未发现发表偏倚的证据。协会的强度与出版年份无关 (即没有证据表明赢家的诅咒)。元回归表明,在评估痴呆、痴呆类型、随访时间长度、样本年龄、少数民族、国家和人格测量的方法中,神经质、开放性和责任心的影响一致。外向性和宜人性的关联因国家而异。我们的研究结果表明神经质和责任心与痴呆风险密切相关。

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作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

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发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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