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Quantitative determination of creatinine from serum of prostate cancer patients by N-doped porous carbon antimony (Sb/NPC) nanoparticles.

N掺杂多孔碳锑 (Sb/NPC) 纳米颗粒定量测定前列腺癌患者血清肌酐。

  • 影响因子:0
  • DOI:10.1016/j.bioelechem.2021.107815
  • 作者列表:"Jamil M","Fatima B","Hussain D","Chohan TA","Majeed S","Imran M","Khan AA","Manzoor S","Nawaz R","Ashiq MN","Najam-Ul-Haq M
  • 发表时间:2021-04-05
Abstract

:Creatinine is an indicator of hindrance in urination and renal insufficiency. Creatinine levels are the marker of the late stages of prostate cancer. Early and sensitive detection of creatinine can reduce deaths associated with prostate cancer. In this work, nitrogen-doped porous carbon antimony (Sb/NPC) nanoparticles are fabricated to be employed as a non-enzymatic biosensor. Sb/NPC has promising redox activity and is synthesized by a two-step reaction using low-cost precursors. Electrochemical sensing by Sb/NPC is conducted for standard creatinine solutions on a three-electrodes system. Cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy are used to sense creatinine. LOD and LOQ of the Sb/NPC modified electrode are 0.74 µM and 2.4 µM, respectively. This electrode system analyzes creatinine in the serum of prostate cancer patients who have elevated PSA levels. More than 90% creatinine is recovered from a spiked serum sample of a prostate cancer patient. A direct relation is observed between PSA levels and creatinine levels in prostate cancer. The developed cyclic voltammetric setup detects trace concentrations of creatinine in serum.

摘要

: 肌酐是排尿障碍和肾功能不全的指标。肌酐水平是前列腺癌晚期的标志物。肌酐的早期和灵敏检测可以减少与前列腺癌相关的死亡。在这项工作中,氮掺杂的多孔碳锑 (Sb/NPC) 纳米颗粒被制备成用作非酶生物传感器。Sb/NPC具有有希望的氧化还原活性,并且通过使用低成本前体的两步反应合成。在三电极系统上对标准肌酸酐溶液进行Sb/NPC的电化学传感。使用循环伏安法、安培法和电化学阻抗谱来检测肌酸酐。Sb/NPC修饰电极的LOD和LOQ分别为0.74微米和2.4微米。该电极系统分析PSA水平升高的前列腺癌患者血清中的肌酸酐。从前列腺癌患者的加标血清样品中回收超过90% 的肌酸酐。在前列腺癌中观察到PSA水平和肌酸酐水平之间的直接关系。开发的循环伏安设置检测血清中肌酸酐的痕量浓度。

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DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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