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Immediate aspiration of the drug infused via central venous catheter through the distally positioned central venous dialysis catheter: An experimental study.

通过远端定位的中心静脉透析导管立即抽吸经中心静脉导管输注的药物: 实验研究。

  • 影响因子:1.12
  • DOI:10.1177/1129729820924555
  • 作者列表:"Vicka V","Vickiene A","Tutkus J","Stanaitis J","Bandzeviciute R","Ringaitiene D","Vosylius S","Sipylaite J
  • 发表时间:2021-01-01
Abstract

OBJECTIVES:The aim of this study was to construct an experimental model replicating blood flow within human superior vena cava and to determine the degree of the immediate aspiration of the drug introduced via central venous catheter through the distally positioned dialysis catheter. METHODS:A model replicating superior vena cava was built, catheters were inserted into the model, placing the orifice of the central venous catheter in positions regarding the orifice of the arterial lumen in central venous dialysis catheter (from +2 to -8 cm). Methylene blue was used as a tracer, and the concentration was determined by ultraviolet-visible spectroscopy. Four different sets of samples were generated according to infusion and aspiration speeds: continuous-slow, continuous-fast, bolus-slow, and bolus-fast. RESULTS:The concentration of the tracer was related to the distance between the catheter tips, representing a bimodal dependence. When the central venous catheter was placed distally to the central venous dialysis catheter, the aspiration of the tracer was minimal. When withdrawing the central venous catheter proximally, the aspiration of the tracer increased, reaching its peak at -4 cm with aspiration rates form 4.2% to 140.7%. Furthermore, the infusion speed of the tracer had more effect on the aspirated concentrations than the aspiration speed. CONCLUSION:Findings of our experimental model suggest that concentration of aspired drug is effected by the distance between the central venous catheter and central venous dialysis catheter, being lowest when the drug is infused distally to central venous dialysis catheter. Furthermore, the concentration of the tracer is directly proportional to the infusion speed and far less effected by the aspiration rate of the drug.

摘要

目的: 本研究的目的是构建一个复制人上腔静脉内血流的实验模型,并确定通过中心静脉导管通过远端定位的透析导管引入的药物的立即吸入程度。 方法: 建立复制上腔静脉的模型,将导管插入模型中,将中心静脉导管的开口放置在中心静脉透析导管中动脉管腔开口的位置 (从 + 2到-8厘米)。以亚甲基蓝为示踪剂,用紫外-可见分光光度法测定其浓度。根据输注和抽吸速度产生四组不同的样品: 连续-慢、连续-快、推注-慢和推注-快。 结果: 示踪剂的浓度与导管尖端之间的距离相关,代表双峰依赖性。当中心静脉导管放置在中心静脉透析导管的远端时,示踪剂的抽吸最小。当向近侧撤回中心静脉导管时,示踪剂的抽吸增加,在-4厘米处达到其峰值,抽吸率为4.2% 至140.7%。此外,示踪剂的输注速度比抽吸速度对抽吸浓度的影响更大。 结论: 我们的实验模型结果表明,所需药物的浓度受中心静脉导管与中心静脉透析导管之间距离的影响,当药物向中心静脉透析导管远端输注时最低。此外,示踪剂的浓度与输注速度成正比,并且受药物的抽吸速率的影响要小得多。

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