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Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support.

左心室辅助装置支持患者新型冠状病毒肺炎的特征和结局。

  • 影响因子:4.83
  • DOI:10.1161/CIRCHEARTFAILURE.120.007957
  • 作者列表:"Birati EY","Najjar SS","Tedford RJ","Houston BA","Shore S","Vorovich E","Atluri P","Urgo K","Molina M","Chambers S","Escobar N","Hsich E","Estep JD","Alexander KM","Teuteberg JJ","Chaudhry SP","Ravichandran A","DeVore AD","Margulies KB","Hanff TC","Zimmer R","Kilic A","Wald JW","Vidula H","Martens J","Blumberg EA","Mazurek JA","Owens AT","Goldberg LR","Alvarez-Garcia J","Mancini DM","Moss N","Genuardi MV
  • 发表时间:2021-04-01
Abstract

BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs. METHODS:The Trans-CoV-VAD registry is a multi-center registry of LVAD and cardiac transplant patients in the United States with confirmed COVID-19. Patient characteristics, exposure history, presentation, laboratory data, course, and clinical outcomes were collected by participating institutions and reviewed by a central data repository. This report represents the participation of the first 9 centers to report LVAD data into the registry. RESULTS:A total of 40 patients were included in this cohort. The median age was 56 years (interquartile range, 46-68), 14 (35%) were women, and 21 (52%) were Black. Among the most common presenting symptoms were cough (41%), fever, and fatigue (both 38%). A total of 18% were asymptomatic at diagnosis. Only 43% of the patients reported either subjective or measured fever during the entire course of illness. Over half (60%) required hospitalization, and 8 patients (20%) died, often after lengthy hospitalizations. CONCLUSIONS:We present the largest case series of LVAD patients with COVID-19 to date. Understanding these characteristics is essential in an effort to improve the outcome of this complex patient population.

摘要

背景: 冠状病毒疾病2019 (新型冠状病毒肺炎) 大流行继续困扰着全球数百万人。患有终末期心力衰竭和左心室辅助装置 (lvad) 的患者可能处于严重新型冠状病毒肺炎的风险中,因为复杂合并症和功能性免疫受损的患病率很高。本研究的目的是描述新型冠状病毒肺炎例终末期心力衰竭和持久lvad患者的临床特征和预后。 方法: Trans-CoV-VAD注册登记是美国LVAD和心脏移植患者的多中心注册登记,确认新型冠状病毒肺炎。参与机构收集患者特征、暴露史、表现、实验室数据、病程和临床结局,并通过中央数据储存库进行审查。该报告代表前9个中心参与将LVAD数据报告到注册表中。 结果: 本队列共纳入40例患者。中位年龄为56岁 (四分位距46-68岁),14名 (35%) 为女性,21名 (52%) 为黑人。最常见的症状是咳嗽 (41%),发热乏力均为38%)。共有18% 例在诊断时无症状。只有43% 的患者在整个病程中报告了主观或测量的发热。超过一半 (60%) 的患者需要住院治疗,8名患者 (20%) 在长期住院治疗后死亡。 结论: 我们提出了迄今为止最大的LVAD患者病例系列,新型冠状病毒肺炎。了解这些特征对于改善这种复杂患者群体的结果至关重要。

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影响因子:2.68
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