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An Approach to Screen Genotoxic-Susceptible Diabetic Population of Various Prakriti Groups for Personalized Disease Management.

筛选不同Prakriti组的遗传毒性易感糖尿病人群进行个性化疾病管理的方法。

  • 影响因子:1.75
  • DOI:10.1089/acm.2020.0001
  • 作者列表:"Banerjee S","Biswas TK","Chattopadhyay K","Arzoo SH","Chattopadhyay B
  • 发表时间:2021-01-01
Abstract

: Background: Ayurveda classifies human populations into three predominant groups as Vata, Pitta, and Kapha based on their "Prakriti'. Any disturbance in the equilibrium of Prakriti can cause various diseases. Objectives: The aim of the study was to link genotoxic variation among the three Prakriti having type 2 diabetes. Design: Type 2 diabetic patients and healthy individuals belonging to three predominant Prakriti were selected through the Prakriti Questionnaire screening as per the guidelines of the CSIR-TRISUTRA unit modified for type 2 diabetes disease. Settings/Location: Sixty individuals from three predominant Prakriti, each consisting of 10 diabetic patients and 10 healthy individuals, were chosen. Subjects: Clinically diagnosed outdoor patients of JBRMCH suffering from type 2 diabetes for 5 years (fasting blood glucose >140 mg/dL; HbA1C > 7.0) and healthy individuals were the subjects for study. Inclusion Criteria: Age limit: 30-70 years, Sex: Both, Habitant: Participants residing in West Bengal for the last five generations, Religion: Unspecified, Social entity: Both urban and rural, Education: High school to college, Economic status: Lower middle to middle classes. Exclusion Criteria: Participants were nonsmokers and nonalcoholics. An individual having a medical history of long-term illness or dwandaja Prakriti type was excluded here. Outcome Measures: Reactive oxygen species (ROS) generation, blood DNA content, DNA damage, apoptosis of blood cells, and interaction of DNA with various carcinogens were observed. Results: The yield of ROS and total cell damage were significantly higher in the diabetic Vata (p < 0.001) group compared with other Prakriti Decreased DNA content and increased DNA damage were observed in type 2 diabetic patients who belonged to Vata (p < 0.01) Prakriti. DNA of Vata Prakriti was more prone to lead and arsenic. Conclusions: The diabetic Vata Prakriti is a genetically susceptible group as it has a tendency to get affected by increased DNA damage, which could help in creating personalized management of diabetes among individual Prakriti.

摘要

: 背景: 阿育吠陀根据其 “prakriti” 将人类群体分为三个主要群体,即Vata、Pitta和Kapha。Prakriti平衡中的任何干扰都可能导致各种疾病。 目标: 该研究的目的是将三种2型糖尿病患者的遗传毒性变异联系起来。 设计: 根据CSIR-TRISUTRA单元针对2型糖尿病疾病修改的指南,通过Prakriti问卷筛选选择属于三种主要Prakriti的2型糖尿病患者和健康个体。 设置/位置: 从三个主要的Prakriti中选择60个个体,每个个体由10个糖尿病患者和10个健康个体组成。 主题: 临床诊断为JBRMCH患有2型糖尿病5年 (空腹血糖> 140 mg/dL; HbA1C > 7.0) 的户外患者和健康者为研究对象。 入选标准: 年龄限制: 30-70岁,性别: 两者都有,居住者: 最近五代居住在西孟加拉邦的参与者,宗教: 未指明,社会实体: 城市和农村,教育: 高中到大学,经济状况: 中下到中产阶级。 排除标准: 参与者为非吸烟者和非酗酒者。此处排除具有长期疾病病史或dwandaja Prakriti型的个体。 结果测量: 观察活性氧 (ROS) 产生、血液DNA含量、DNA损伤、血细胞凋亡以及DNA与各种致癌物的相互作用。 结果: 糖尿病Vata (p <0.001) 组的ROS产量和总细胞损伤显著高于其他Prakriti,在属于Vata (p <0.01) 的2型糖尿病患者中观察到DNA含量降低和DNA损伤增加。Vata Prakriti的DNA更容易出现铅和砷。 结论: 糖尿病患者Vata Prakriti是一个遗传易感群体,因为它有受到DNA损伤增加影响的趋势,这可能有助于在个体Prakriti中创建糖尿病的个性化管理。

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