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Systematic Review on the Use of Homeopathy in Dentistry: Critical Analysis of Clinical Trials.

系统评价顺势疗法在牙科中的应用: 临床试验的批判性分析。

  • 影响因子:1.75
  • DOI:10.1089/acm.2020.0271
  • 作者列表:"Amaral TG","Zina LG","Paula JS
  • 发表时间:2021-03-01
Abstract

: Objectives: The objective of this research was to systematically map the literature on homeopathy and dentistry studies and to evaluate the effectiveness of using homeopathy in dental practice through the critical analysis of clinical studies. Design: The search for scientific articles in any language, year, and place of publication was made in the databases of Public Medline (PUBMED), Web of Science, Cochrane, and Virtual Health Library; the articles selected were later classified according to the type of study. Gray literature was accessed through Google Scholar. Clinical trials were analyzed for methodological quality. Two previously trained reviewers accomplished the entire process independently. Results: Of the 281 studies retrieved by means of the search, 44 met the eligibility criteria, with prevalence of literature reviews (56.8%), followed by clinical trials (34.1%), cross-sectional studies (6.8%), laboratory research (6.8%), and longitudinal observational studies (4.5%). The clinical trials identified were published from 1965 to 2019, using homeopathy in several dental specialties: in Endodontics, Periodontics, Orofacial Pain, Surgery, Pediatric Dentistry, and Stomatology, as well as in cases of dental anxiety. Qualitative failures, in all criteria investigated, and positive influences of the individual prescriptions on the results of treatments reported were observed. Conclusions: There is still a scarcity of studies about homeopathy and dentistry. The clinical trials selected showed positive effects on oral health; however, when they were critically evaluated, it was possible to recognize qualitative failures, mainly relative to double-blinding. It is necessary to encourage research on the subject, using standardized methodological procedures, to obtain better evaluation of the clinical applicability.

摘要

: 目标: 这项研究的目的是系统地绘制关于顺势疗法和牙科研究的文献,并通过临床研究的批判性分析来评估在牙科实践中使用顺势疗法的有效性。 设计: 在公共Medline (PUBMED) 、Web of Science、Cochrane和虚拟健康图书馆数据库中搜索任何语言、年份和发表地点的科学文章; 随后根据研究类型对所选文章进行分类.灰色文献是通过Google Scholar访问的。分析临床试验的方法学质量。两名之前接受过培训的审核者独立完成了整个过程。 结果: 在通过检索检索到的281项研究中,44项符合纳入标准,文献综述 (56.8%) 普遍,其次是临床试验 (34.1%) 、横断面研究 (6.8%) 、实验室研究 (6.8%) 和纵向观察性研究 (4.5%)。确定的临床试验发表于1965年至2019年,在几个牙科专业中使用顺势疗法: 牙髓病学,牙周病学,口腔面部疼痛,外科,儿童牙科和口腔科,以及牙科焦虑。在所研究的所有标准中,观察到定性失败,以及个体处方对所报告的治疗结果的积极影响。 结论: 关于顺势疗法和牙科的研究仍然很少。选择的临床试验显示对口腔健康的积极影响; 然而,当对它们进行批判性评估时,可以识别定性失败,主要是相对于双盲。有必要鼓励对该主题的研究,使用标准化的方法学程序,以获得更好的临床适用性评价。

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影响因子:2.68
发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.

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发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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