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Effects of Korean Red Ginseng (Panax ginseng C.A. Meyer) on Menopausal Symptoms in Premenopausal Women After Gynecologic Cancer Surgery: A Double-Blind, Randomized Controlled Trial.

韩国红参的作用 (人参C.A.Meyer) 对绝经前妇女妇科肿瘤术后更年期症状的影响: 一项双盲、随机对照试验。

  • 影响因子:1.75
  • DOI:10.1089/acm.2019.0429
  • 作者列表:"Chung YS","Lee IO","Lee JY","Nam EJ","Kim SW","Kim YT","Kim S
  • 发表时间:2021-01-01
Abstract

: Objectives: Korean red ginseng (KRG) has been widely used as an alternative medicine to relieve menopausal symptoms. However, there is still a lack of clinical studies showing the effects of KRG on menopausal symptoms after gynecologic cancer surgery. Therefore, the authors investigated the effects of KRG on surgical menopause symptoms in premenopausal women with gynecologic cancer. Design: A double-blind, randomized, placebo-controlled clinical trial was conducted. Settings/Location: The study was performed at Severance Hospital at the Yonsei University College of Medicine in Seoul, Korea. Subjects: Fifty-five premenopausal women diagnosed with gynecologic cancer were enrolled in the study. Interventions: Patients were randomly assigned to a KRG (n = 29) or a placebo control group (n = 26). Subjects were administered either KRG (a total of 3 g per day) or placebo supplements for 12 weeks. Outcome measures: Patients' physical measurements (height, weight, and blood pressure) and blood samples (lipid profiles, hormone profiles, biochemical profiles, and neutrophil-to-lymphocyte ratio) at baseline and at 12 weeks were compared. Changes in menopausal symptoms based on the Menopause Rating Scale (MRS) were also compared between these two time points and two groups. Results: After 12 weeks, the MRS score was significantly reduced in each group (p = 0.001 and p = 0.001, respectively), but there were no significant differences between the two groups (p = 0.661). No adverse events were observed in either group. After comparing 11 MRS symptoms between the two groups, the KRG group seemed to be superior to the placebo group on the subscale of sexual complaints (p < 0.05). Conclusions: Through the study, KRG did not show absolute relief of surgical menopause symptoms in premenopausal women after gynecologic cancer surgery. However, the study did demonstrate that KRG may be effective in reducing sexual complaints. Further studies are required to evaluate the long-term effects of KRG in a larger patient population.

摘要

: 目标: 韩国红参 (KRG) 已被广泛用作缓解更年期症状的替代药物。然而,仍缺乏临床研究显示KRG对妇科癌症术后更年期症状的影响。因此,作者研究了KRG对绝经前妇科肿瘤妇女手术绝经症状的影响。 设计: 进行双盲、随机、安慰剂对照临床试验。 设置/位置: 该研究在韩国首尔延世大学医学院的Severance医院进行。 主题: 55名被诊断患有妇科癌症的绝经前妇女参加了这项研究。 干预措施: 患者被随机分配到KRG组 (n = 29) 或安慰剂对照组 (n = 26)。受试者施用KRG (每天总共3 μ g) 或安慰剂补充剂12周。 结果测量: 比较基线和12周时患者的身体测量 (身高,体重和血压) 和血液样本 (血脂谱,激素谱,生化谱和中性粒细胞与淋巴细胞的比率)。根据绝经评定量表 (MRS) 对两组患者的绝经症状变化进行比较。 结果: 12周后,各组MRS评分均显著降低 (p   = 0.001,p   = 0.001),但两组间差异无统计学意义 (p   = 0.661)。两组均未观察到不良事件。在比较两组之间的11个MRS症状后,KRG组在性抱怨的分量表上似乎优于安慰剂组 (p <0.05)。 结论: 通过研究,KRG没有显示出妇科癌症手术后绝经前妇女手术绝经症状的绝对缓解。然而,这项研究确实证明了KRG可能有效减少性抱怨。需要进一步的研究来评估KRG在更大的患者群体中的长期作用。

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