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Effect of Equine-Assisted Activities on Cardiac Autonomic Function in Children with Cerebral Palsy: A Pilot Randomized-Controlled Trial.

马辅助活动对脑瘫儿童心脏自主神经功能的影响: 一项随机对照试验。

  • 影响因子:1.75
  • DOI:10.1089/acm.2020.0346
  • 作者列表:"Park IK","Lee JY","Suk MH","Yoo S","Seo YG","Oh JK","Kwon JY
  • 发表时间:2021-01-01
Abstract

: Objective: Children with cerebral palsy (CP) have an impaired cardiac autonomic function. Attenuated heart rate recovery (HRR), which is a valuable prognostic parameter for autonomic nervous system, is known to be associated with an increased risk of cardiovascular events and all-cause mortality. However, only few studies have observed the effects of exercise on the cardiac autonomic function in children with CP. The purpose of this pilot study was to examine the effects of equine-assisted activity (EAA) program on cardiac autonomic function in children with CP. Design: A single-blinded, parallel, two-arm pilot trial with 1:1 randomization to the EAA or control group. Setting: A tertiary university hospital and a local arena. Subjects: Twenty-six children with CP (Gross Motor Function Classification System Levels I-II). Intervention: Each lesson of the EAA program for the EAA group was conducted for 40 min twice a week, and the whole program duration was 16 weeks (a total of 32 sessions). Outcome measures: A graded exercise test was performed to measure the resting heart rate (RHR), HRR, and peak oxygen uptake (VO2peak) on both groups before and after the 16-week period. Results: The autonomic nervous function measured by the response of HRR improved at 1 min (p < 0.009), 3 min (p < 0.001), and 5 min (p < 0.004) only in the EAA group. RHR significantly improved in the EAA group (p < 0.013), whereas the VO2peak did not significantly differ between the two groups. Conclusion: The HRR and RHR of the children with CP improved after completing the 16-week EAA program. The results demonstrated that the program had a positive effect on the improvement of cardiac autonomic function in these patients. Clinical Trial Registration Number: NCT03870893.

摘要

: 目的: 脑瘫 (CP) 患儿心脏自主神经功能受损。心率恢复减弱 (HRR) 是自主神经系统的一个有价值的预后参数,已知其与心血管事件和全因死亡率的风险增加相关。然而,只有很少的研究观察到运动对CP儿童心脏自主神经功能的影响。这项初步研究的目的是检查马辅助活动 (EAA) 计划对CP儿童心脏自主神经功能的影响。 设计: 一项1:1随机分配至EAA或对照组的单盲、平行、双臂试验. 设置: 三级大学医院和当地竞技场。 主题: 26例CP患儿 (粗大运动功能分级系统 ⅰ-ⅱ 级)。 干预: EAA组EAA项目的每节课每周进行两次,每次40  min,整个项目持续时间为16周 (共32次)。 结果测量: 进行分级运动试验,测量16周前后两组的静息心率 (RHR) 、HRR和峰值摄氧量 (VO2peak)。 结果: 通过HRR反应测量的自主神经功能仅在EAA组在1  min (p <0.009) 、3  min (p <0.001) 和5  min (p <0.004) 时改善。RHR在EAA组中显著改善 (p <0.013),而VO2peak在两组之间没有显著差异。 结论: 在完成16周EAA项目后,患有CP的儿童的HRR和RHR有所改善。结果表明,该方案对改善这些患者的心脏自主神经功能具有积极作用。临床试验注册号: nct03870893。

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