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Glucosamine and Chondroitin Use in Relation to C-Reactive Protein Concentration: Results by Supplement Form, Formulation, and Dose.

葡萄糖胺和软骨素的使用与C反应蛋白浓度的关系: 补充形式、制剂和剂量的结果。

  • 影响因子:0
  • DOI:10.1089/acm.2020.0283
  • 作者列表:"Kantor ED","O'Connell K","Du M","Cao C","Zhang X","Lee DH","Cao Y","Giovannucci EL
  • 发表时间:2021-02-01
Abstract

: Objectives: Glucosamine and chondroitin supplements have been associated with reduced inflammation, as measured by C-reactive protein (CRP). It is unclear if associations vary by formulation (glucosamine alone vs. glucosamine+chondroitin), form (glucosamine hydrochloride vs. glucosamine sulfate), or dose. Design, Subjects, Setting, Location: The authors evaluated these questions using cross-sectional data collected between 1999 and 2010 on 21,917 US adults, surveyed as part of the National Health and Nutrition Examination Survey (NHANES). Exposures: Glucosamine and chondroitin use was assessed during an in-home interview; exposures include supplement formulation, form, and dose. Outcome/Analysis: CRP was measured using blood collected at interview. Survey-weighted linear regression was used to evaluate the multivariable-adjusted association between exposures and log-transformed CRP. Results: In early years (1999-2004), use of glucosamine (ratio = 0.87; 95% confidence interval [CI] = 0.79-0.96) and chondroitin (ratio = 0.83; 95% CI = 0.72-0.95) was associated with reduced CRP. However, associations significantly varied by calendar time (p-interaction = 0.04 and p-interaction = 0.01, respectively), with associations nonsignificant in later years (ratio = 1.09; 95% CI = 0.94-1.28 and ratio = 1.16; 95% CI = 0.99-1.35, respectively). Consequently, all analyses have been stratified by calendar time. Associations did not significantly differ by formulation in either set of years; however, significant associations were observed for combined use of glucosamine+chondroitin (ratioearly = 0.82; 95% CI = 0.72-0.95; ratiolate = 1.16; 1.00-1.35), but not glucosamine alone. Associations also did not significantly differ by supplement form. Even so, a significant inverse association was observed only for glucosamine sulfate in the early years (ratio = 0.78; 95% CI = 0.64-0.95); no significant association was observed for glucosamine hydrochloride. No significant trends were observed by dose. Conclusions: Although a significant inverse association was observed for glucosamine and chondroitin and CRP in early years, this association did not hold in later years. This pattern held for combined use of glucosamine+chondroitin as well as glucosamine sulfate, although associations did not significantly vary by supplement form, formulation, or dose. Further study is needed to better understand these associations in the context of calendar time.

摘要

: 目标: 通过C-反应蛋白 (CRP) 测量,葡萄糖胺和软骨素补充剂与减少的炎症有关。不清楚关联是否因制剂 (单独的葡糖胺与葡糖胺 + 软骨素) 、形式 (葡糖胺盐酸盐与葡糖胺硫酸盐) 或剂量而异。 设计,主题,设置,位置: 作者使用1999年至2010年间收集的21,917名美国成年人的横断面数据评估了这些问题,这些数据是作为国家健康和营养调查 (NHANES) 的一部分进行调查的。 曝光: 在家庭访谈期间评估葡萄糖胺和软骨素的使用; 暴露包括补充制剂,形式和剂量。 结果/分析: 使用访谈时收集的血液测量CRP。使用调查加权线性回归来评估暴露和对数转换的CRP之间的多变量调整的关联。 结果: 在早期 (1999-2004),使用氨基葡萄糖 (比率 = 0.87; 95% 置信区间 [CI] = 0.79-0.96) 和软骨素 (比率 = 0.83; 95% CI = 0.72-0.95) 与CRP降低相关。然而,关联随日历时间显著变化 (p相互作用   =   0.04,p相互作用respectively =   0.01),关联在晚年不显著 (比率   =   1.09; 95% ci   =   0.94-1.28,比率   =   1.16; 95% ci   =   0.99-1.35,分别)。因此,所有分析均按日历时间分层。在两组年份中,制剂之间的相关性没有显著差异; 然而,在氨基葡萄糖 + 软骨素的联合使用中观察到显著的相关性 (比率ear= 0.82; 95% ci   = 0.72-0.95; 比率   = 1.16; 1.00-1.35),但不是单独的氨基葡萄糖。不同补充形式的协会也没有显著差异。即便如此,早期仅对硫酸氨基葡萄糖观察到显著的逆关联 (比率   =   0.78; 95% ci   =   0.64-0.95); 对盐酸氨基葡萄糖没有观察到显著关联。未观察到剂量的显著趋势。 结论: 虽然在早期观察到葡糖胺和软骨素和CRP的显著逆关联,但这种关联在以后的几年中不成立。这种模式适用于葡糖胺 + 软骨素以及葡糖胺硫酸盐的组合使用,尽管相关性在补充剂形式、制剂或剂量方面没有显著变化。需要进一步研究以更好地理解日历时间背景下的这些关联。

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