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The dark side of the gut: Virome-host interactions in intestinal homeostasis and disease.

肠道的阴暗面: 肠道稳态和疾病中的病毒-宿主相互作用。

  • 影响因子:9.83
  • DOI:10.1084/jem.20201044
  • 作者列表:"Li Y","Handley SA","Baldridge MT
  • 发表时间:2021-05-03
Abstract

:The diverse enteric viral communities that infect microbes and the animal host collectively constitute the gut virome. Although recent advances in sequencing and analysis of metaviromes have revealed the complexity of the virome and facilitated discovery of new viruses, our understanding of the enteric virome is still incomplete. Recent studies have uncovered how virome-host interactions can contribute to beneficial or detrimental outcomes for the host. Understanding the complex interactions between enteric viruses and the intestinal immune system is a prerequisite for elucidating their role in intestinal diseases. In this review, we provide an overview of the enteric virome composition and summarize recent findings about how enteric viruses are sensed by and, in turn, modulate host immune responses during homeostasis and disease.

摘要

感染微生物和动物宿主的不同肠道病毒群落共同构成肠道病毒。虽然最近在亚病毒测序和分析方面的进展已经揭示了病毒的复杂性并促进了新病毒的发现,但是我们对肠病毒的理解仍然是不完整的。最近的研究揭示了病毒-宿主相互作用如何有助于对宿主有益或有害的结果。了解肠道病毒和肠道免疫系统之间复杂的相互作用是阐明它们在肠道疾病中的作用的先决条件。在这篇综述中,我们提供了肠道病毒组合物的概述,并总结了最近关于肠道病毒如何被体内平衡和疾病期间的宿主免疫应答所感知并反过来调节的发现。

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影响因子:2.68
发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

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发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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