Prospective Clinical Evaluation of Posterior Monolithic Zirconia Fixed Partial Dentures Using a Complete Digital Workflow: Two-Year Follow-Up.
- 作者列表："Pontevedra P","Lopez-Suarez C","Pelaez J","Garcia-Serdio S","Suarez MJ
PURPOSE:To evaluate the clinical performance and survival rate of posterior monolithic zirconia fixed partial dentures over a 2-year period. MATERIAL AND METHODS:A total of 20 patients, requiring 20 posterior fixed partial dentures were included in the study. Tooth preparations were scanned, and restorations were milled and cemented with a resin cement. The restorations were assessed for the quality of the surface and the color, anatomical form and marginal integrity. Periodontal status was assessed by determining the plaque index, gingival index, pocket depth, and margin index of the abutment teeth. Data were statistically analyzed using the Friedman and the Wilcoxon signed-rank tests with the Bonferroni correction. RESULTS:The survival rate at 2 years was 100%, and no biological or technical complications were observed. All restorations were assessed as satisfactory. The results obtained for gingival index and plaque index were better at 2 years follow-up, than at baseline. The margin index remained stable throughout the follow-up period. No differences in periodontal parameters were observed between abutment and control teeth. CONCLUSIONS:The high survival rate after 2 years suggest that monolithic zirconia may be an acceptable alternative to metal-ceramic and veneered zirconia restorations in the posterior region. Additional long-term, controlled studies are necessary to confirm the results.
前言: 目的: 评价后路整体氧化锆固定局部义齿的临床性能和2年生存率。 材料和方法: 本研究共纳入20例患者，需要20个后牙固定部分义齿。扫描牙齿制备物，并用树脂粘固剂研磨和粘合修复体。评估修复体的表面质量和颜色、解剖形式和边缘完整性。通过测定基牙的菌斑指数、牙龈指数、口袋深度和边缘指数来评估牙周状况。使用Friedman和Wilcoxon符号秩检验以及Bonferroni校正对数据进行统计分析。 结果: 2年生存率为100%，无生物学或技术并发症。所有修复体评价为满意。2年随访时，牙龈指数和菌斑指数的结果优于基线。边缘指数在整个随访期间保持稳定。在基牙和对照牙之间未观察到牙周参数的差异。 结论: 2年后的高存活率表明，整体氧化锆可能是后区域金属陶瓷和贴面氧化锆修复的可接受的替代品。需要额外的长期对照研究来证实结果。
METHODS::The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.
METHODS::Since the discovery of dental pulp stem cells, a lot of teams have expressed an interest in dental pulp regeneration. Many approaches, experimental models and biological explorations have been developed, each including the use of stem cells and scaffolds with the final goal being clinical application in humans. In this review, the authors' objective was to compare the experimental models and strategies used for the development of biomaterials for tissue engineering of dental pulp with stem cells. Electronic queries were conducted on PubMed using the following terms: pulp regeneration, scaffold, stem cells, tissue engineering and biomaterial. The extracted data included the following information: the strategy envisaged, the type of stem cells, the experimental models, the exploration or analysis methods, the cytotoxicity or viability or proliferation cellular tests, the tests of scaffold antibacterial properties and take into account the vascularization of the regenerated dental pulp. From the 71 selected articles, 59% focused on the "cell-transplantation" strategy, 82% used in vitro experimentation, 58% in vivo animal models and only one described an in vivo in situ human clinical study. 87% used dental pulp stem cells. A majority of the studies reported histology (75%) and immunohistochemistry explorations (66%). 73% mentioned the use of cytotoxicity, proliferation or viability tests. 48% took vascularization into account but only 6% studied the antibacterial properties of the scaffolds. This article gives an overview of the methods used to regenerate dental pulp from stem cells and should help researchers create the best development strategies for research in this field.