Comparison of Intaglio Surface Adjustment in the Oral Cavity for Lithium Disilicate Crowns Fabricated Using Different Scanners.
- 作者列表："Son K","Yu BY","Lee JH","Son YT","Lee KB
PURPOSE:A clinical study to evaluate the intraoral adjustment of crowns fabricated using different scanners. MATERIALS AND METHODS:A total of 15 patients requiring single ceramic crowns were recruited. Impressions were made according to four protocols: a conventional approach and using three intraoral scanners (IOSs) (CS3600 (Carestream Dental, Atlanta, GA), i500 (Medit, Seoul, Republic of Korea), and EZIS PO (DDS, Seoul, Republic of Korea)). Four crowns per patient were fabricated using lithium disilicate ceramic. An experienced dentist performed the internal adjustment in the oral cavity. Three-dimensional analysis was conducted using an inspection software program (Geomagic Control X; 3D Systems, Rock Hill, SC). Statistical analysis was conducted using one-way analysis of variance and Tukey's honest significance difference tests (α = 0.05). RESULTS:A significant difference was observed in the intraoral adjustment among the conventional approach and the three IOSs (F = 213.7, p < 0.001). Crowns fabricated by conventional impressions (20.1 ± 1.4 µm) displayed better three-dimensional conformity before and after intraoral adjustment than IOS groups (29.6 ± 4.3 µm) (p < 0.001). CONCLUSIONS:Crowns fabricated using conventional impressions required fewer intraoral adjustments of the intaglio surface than those fabricated using IOSs.
目的: 评价使用不同扫描仪制作的牙冠口内调整的临床研究。 材料和方法: 共纳入15例需要单个烤瓷冠的患者。根据四种方案进行印象: 常规方法和使用三种口内扫描仪 (IOSs) (CS3600 (Carestream Dental，Atlanta，GA) 、i500 (Medit，Seoul，大韩民国) 和EZIS PO (DDS，Seoul，大韩民国))。使用二硅酸锂陶瓷制造每个患者四个牙冠。一位经验丰富的牙医在口腔中进行了内部调整。使用检查软件程序 (Geomagic Control X; 3D Systems，Rock Hill，SC) 进行三维分析。使用单因素方差分析和Tukey 's诚实显著性差异检验 (α = 0.05) 进行统计分析。 结果: 常规入路与三种IOSs在口内调节方面差异有统计学意义 (F = 213.7，p <0.001)。常规印模制作的牙冠 (20.1 ± 1.4 µ m) 在口内调整前后显示出比IOS组 (29.6 ± 4.3 µ m) 更好的三维一致性 (p <0.001)。 结论: 与使用IOSs制作的牙冠相比，使用常规印模制作的牙冠需要较少的凹版表面口内调整。
METHODS::The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.
METHODS::Since the discovery of dental pulp stem cells, a lot of teams have expressed an interest in dental pulp regeneration. Many approaches, experimental models and biological explorations have been developed, each including the use of stem cells and scaffolds with the final goal being clinical application in humans. In this review, the authors' objective was to compare the experimental models and strategies used for the development of biomaterials for tissue engineering of dental pulp with stem cells. Electronic queries were conducted on PubMed using the following terms: pulp regeneration, scaffold, stem cells, tissue engineering and biomaterial. The extracted data included the following information: the strategy envisaged, the type of stem cells, the experimental models, the exploration or analysis methods, the cytotoxicity or viability or proliferation cellular tests, the tests of scaffold antibacterial properties and take into account the vascularization of the regenerated dental pulp. From the 71 selected articles, 59% focused on the "cell-transplantation" strategy, 82% used in vitro experimentation, 58% in vivo animal models and only one described an in vivo in situ human clinical study. 87% used dental pulp stem cells. A majority of the studies reported histology (75%) and immunohistochemistry explorations (66%). 73% mentioned the use of cytotoxicity, proliferation or viability tests. 48% took vascularization into account but only 6% studied the antibacterial properties of the scaffolds. This article gives an overview of the methods used to regenerate dental pulp from stem cells and should help researchers create the best development strategies for research in this field.